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Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo
BACKGROUND: There is evidence that sirtuin 1 (SIRT1), a key regulator of nutrient metabolism, increases β-cell secretory function. Excess circulating fat, as seen in obesity, has been shown to decrease β-cell function, an effect that may involve decreased SIRT1 activity. Consequently, SIRT1 activati...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424971/ https://www.ncbi.nlm.nih.gov/pubmed/30890694 http://dx.doi.org/10.1038/s41387-019-0075-z |