Cargando…

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

Dopamine (DA) release in striatum is functionally segregated across a dorsolateral/ventromedial axis. Interestingly, nigrostriatal DA signaling disruption in Parkinson’s disease (PD) preferentially affects the dorsolateral striatum. The relationship between afferent presynaptic calcium transients (P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sgobio, Carmelo, Sun, Lixin, Ding, Jinhui, Herms, Jochen, Lovinger, David M., Cai, Huaibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425036/ https://www.ncbi.nlm.nih.gov/pubmed/30890737 http://dx.doi.org/10.1038/s41598-019-41091-7

Ejemplares similares

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease
por: Cai, Huaibin, et al.
Publicado: (2014)

Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology
por: Sun, Fanfan, et al.
Publicado: (2021)

Optogenetic Measurement of Presynaptic Calcium Transients Using Conditional Genetically Encoded Calcium Indicator Expression in Dopaminergic Neurons
por: Sgobio, Carmelo, et al.
Publicado: (2014)

Aldehyde dehydrogenase 1–positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum
por: Sgobio, Carmelo, et al.
Publicado: (2017)

No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models
por: Sastry, Namratha, et al.
Publicado: (2015)

Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson’s Disease
por: Carmichael, Kathleen, et al.
Publicado: (2021)

Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities
por: Yu, Jia, et al.
Publicado: (2023)

Ectopic Pregnancy-Derived Human Trophoblastic Stem Cells Regenerate Dopaminergic Nigrostriatal Pathway to Treat Parkinsonian Rats
por: Lee, Tony Tung-Yin, et al.
Publicado: (2012)

Retraction: Ectopic Pregnancy-Derived Human Trophoblastic Stem Cells Regenerate Dopaminergic Nigrostriatal Pathway to Treat Parkinsonian Rats
Publicado: (2021)

Naringin: A Protector of the Nigrostriatal Dopaminergic Projection
por: Jung, Un Ju, et al.
Publicado: (2014)

Nigrostriatal dopaminergic depletion increases static orofacial allodynia
por: Dieb, Wisam, et al.
Publicado: (2016)

Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission
por: Qin, Qi, et al.
Publicado: (2016)

Selective Vulnerability in Striosomes and in the Nigrostriatal Dopaminergic Pathway After Methamphetamine Administration: Early Loss of TH in Striosomes After Methamphetamine
por: Granado, Noelia, et al.
Publicado: (2009)

Progressive Axonal Degeneration of Nigrostriatal Dopaminergic Neurons in Calcium-Independent Phospholipase A(2)β Knockout Mice
por: Beck, Goichi, et al.
Publicado: (2016)

A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration
por: Singh, Anand Kumar, et al.
Publicado: (2012)

Dopa-responsive dystonia: a syndrome of selective nigrostriatal dopaminergic deficiency.
por: Jeon, B. S.
Publicado: (1997)

Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia
por: Dieb, Wisam, et al.
Publicado: (2014)

Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism
por: Lee, Seung Ha, et al.
Publicado: (2017)

Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System
por: Song, Xiao-Yao, et al.
Publicado: (2015)

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease
por: Tabata, Yoshikuni, et al.
Publicado: (2018)

In vivo Assessment of the Human Nigrostriatal Dopaminergic System Using Positron Emission Tomography
por: Leenders, K. L.
Publicado: (1992)

CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes
por: Zhang, Wenlong, et al.
Publicado: (2020)

NADPH Oxidase and the Degeneration of Dopaminergic Neurons in Parkinsonian Mice
por: Hernandes, Marina S., et al.
Publicado: (2013)

Conditioned Medium Protects Dopaminergic Neurons in Parkinsonian Rats
por: Nakhaeifard, Malihe, et al.
Publicado: (2018)

Different Dopaminergic Dysfunctions Underlying Parkinsonian Akinesia and Tremor
por: Caligiore, Daniele, et al.
Publicado: (2019)

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit
por: Pham, Anh H., et al.
Publicado: (2012)

Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
por: Lee, Yang Hyun, et al.
Publicado: (2019)

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration
por: Pellegrini, Carolina, et al.
Publicado: (2016)

Urinary Dysfunction Is Associated with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson's Disease
por: Wang, Jing, et al.
Publicado: (2020)

Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease: removing axonal debris
por: Morales, Ingrid, et al.
Publicado: (2021)

A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors
por: Kolacheva, A. A., et al.
Publicado: (2021)

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
por: Ciron, C., et al.
Publicado: (2012)

Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion: a possible compensatory mechanism in Parkinson’s disease
por: Blesa, Javier, et al.
Publicado: (2011)

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2015)

Is nigrostriatal dopaminergic deficit necessary for Holmes tremor to develop? The DaTSCAN and IBZM SPECT study
por: Gajos, Agata, et al.
Publicado: (2017)

7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents
por: Nie, Shuke, et al.
Publicado: (2019)

Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats
por: Shin, Mal-Soon, et al.
Publicado: (2017)

Naringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain
por: Kim, Sang Ryong
Publicado: (2017)

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression
por: Wang, Yong, et al.
Publicado: (2020)

Adolescent Exposure to WIN 55212-2 Render the Nigrostriatal Dopaminergic Pathway Activated During Adulthood
por: Pérez-Valenzuela, Enzo Javier, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h9n2le9sftdij0tck48jplsfnh