Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors

Association of soft tissue infection in the extremity with glucose and lipid metabolism as well as inflammatory factors was investigated. One hundred and twenty-six patients with diabetes mellitus (DM) complicated with soft tissue infection in the lower extremity admitted and treated in Dongying People's Hospital from March 2016 to February 2017 were selected and divided into mild (n=46), moderate (n=43) and severe group (n=37) according to the severity of the soft tissue infection in the lower extremity. The glucose and lipid metabolism, inflammatory factors and influencing factors were compared among different groups of patients before treatment, and the changes in glucose and lipid metabolism as well as inflammatory factors were observed after treatment. Before treatment, the levels of free fatty acid (FFA), fasting plasma glucose (FPG), fasting insulin (FINS), vascular cell adhesion molecule-1 (VCAM-1), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in mild group were remarkably lower than those in moderate and severe groups, while the serum adiponectin (APN) level was obviously higher (P<0.05). Logistic regression analysis indicated that FFA, FPG, FINS, APN, VCAM-1, CRP, TNF-α and IL-6 were risk factors influencing soft tissue infection in the extremity (P<0.05). After treatment, among the 126 patients, the levels of FFA, FPG, FINS, VCAM-1, CRP, TNF-α and IL-6 were decreased markedly, while the APN level was increased evidently (P<0.05). Compared with patients innon-toe/extremity amputation group, patients in toe/extremity amputation group had elevated levels of FFA, FPG, FINS, VCAM-1, CRP, TNF-α and IL-6 as well as declined APN level (P<0.05). Glucose and lipid metabolism and inflammatory factors are closely related to soft tissue infection in the extremity.