Palmitic acid-induced autophagy increases reactive oxygen species via the Ca(2+)/PKCα/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells

It is well known that the lipotoxic mechanism of palmitic acid (PA), a main constituent of triglyceride, is dependent on reactive oxygen species (ROS). Recently, it has also been reported that PA is an autophagy inducer. However, the causal association and underlying mechanism of induced autophagy a...

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Detalles Bibliográficos
Autores principales: Chen, Pan, Liu, Hengdao, Xiang, Hong, Zhou, Jianda, Zeng, Zhengpeng, Chen, Ruifang, Zhao, Shaoli, Xiao, Jie, Shu, Zhihao, Chen, Shuhua, Lu, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425131/
https://www.ncbi.nlm.nih.gov/pubmed/30906429
http://dx.doi.org/10.3892/etm.2019.7269

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