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Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis

BACKGROUND: Some studies have reported that renal dysfunction is associated with poor prognosis in cirrhotic patients. Serum cystatin C (CysC) is an accurate biomarker for early renal dysfunction. This study aimed to assess the prognostic value of serum CysC levels in patients with hepatitis B virus...

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Detalles Bibliográficos
Autores principales: Wu, JianPing, Wu, QianXia, Wu, MinYi, Mao, WeiLin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425319/
https://www.ncbi.nlm.nih.gov/pubmed/30949507
http://dx.doi.org/10.1155/2019/7272045
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author Wu, JianPing
Wu, QianXia
Wu, MinYi
Mao, WeiLin
author_facet Wu, JianPing
Wu, QianXia
Wu, MinYi
Mao, WeiLin
author_sort Wu, JianPing
collection PubMed
description BACKGROUND: Some studies have reported that renal dysfunction is associated with poor prognosis in cirrhotic patients. Serum cystatin C (CysC) is an accurate biomarker for early renal dysfunction. This study aimed to assess the prognostic value of serum CysC levels in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi). METHODS: This retrospective study included 75 subjects who had been diagnosed with HBV-DeCi. The association between serum CysC and prognosis was estimated by receiver operating characteristic curve analysis and a multivariable logistic regression model. RESULTS: Serum CysC levels were higher in nonsurvivors than in survivors and were positively correlated with model for end-stage liver disease (MELD) scores. In multivariate analysis, CysC and the MELD score were independent prognostic factors in all HBV-DeCi patients. However, only serum CysC was an independent factor predicting mortality in patients with normal creatinine levels. CONCLUSIONS: These data suggest that high serum CysC levels can be considered an independent biomarker of 3-month mortality in patients with HBV-DeCi.
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spelling pubmed-64253192019-04-04 Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis Wu, JianPing Wu, QianXia Wu, MinYi Mao, WeiLin Biomed Res Int Research Article BACKGROUND: Some studies have reported that renal dysfunction is associated with poor prognosis in cirrhotic patients. Serum cystatin C (CysC) is an accurate biomarker for early renal dysfunction. This study aimed to assess the prognostic value of serum CysC levels in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi). METHODS: This retrospective study included 75 subjects who had been diagnosed with HBV-DeCi. The association between serum CysC and prognosis was estimated by receiver operating characteristic curve analysis and a multivariable logistic regression model. RESULTS: Serum CysC levels were higher in nonsurvivors than in survivors and were positively correlated with model for end-stage liver disease (MELD) scores. In multivariate analysis, CysC and the MELD score were independent prognostic factors in all HBV-DeCi patients. However, only serum CysC was an independent factor predicting mortality in patients with normal creatinine levels. CONCLUSIONS: These data suggest that high serum CysC levels can be considered an independent biomarker of 3-month mortality in patients with HBV-DeCi. Hindawi 2019-03-04 /pmc/articles/PMC6425319/ /pubmed/30949507 http://dx.doi.org/10.1155/2019/7272045 Text en Copyright © 2019 JianPing Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, JianPing
Wu, QianXia
Wu, MinYi
Mao, WeiLin
Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
title Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
title_full Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
title_fullStr Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
title_full_unstemmed Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
title_short Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
title_sort serum cystatin c predicts mortality in hbv-related decompensated cirrhosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425319/
https://www.ncbi.nlm.nih.gov/pubmed/30949507
http://dx.doi.org/10.1155/2019/7272045
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