Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome

A 41-year-old woman developed nephrotic syndrome at the age of 32 and was diagnosed with minimal change nephrotic syndrome based on a renal biopsy. Although remission was achieved with administration of prednisolone (PSL) and cyclosporine, the nephrotic syndrome recurred. She was also started on rit...

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Autores principales: Yamazaki, Mayuko, Sugiura, Hidekazu, Iwatani, Yosuke, Kyoda, Mizuki, Nokiba, Hirohiko, Amemiya, Nobuyuki, Nitta, Kosaku, Tsuchiya, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425356/
https://www.ncbi.nlm.nih.gov/pubmed/30956827
http://dx.doi.org/10.1155/2019/3580941
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author Yamazaki, Mayuko
Sugiura, Hidekazu
Iwatani, Yosuke
Kyoda, Mizuki
Nokiba, Hirohiko
Amemiya, Nobuyuki
Nitta, Kosaku
Tsuchiya, Ken
author_facet Yamazaki, Mayuko
Sugiura, Hidekazu
Iwatani, Yosuke
Kyoda, Mizuki
Nokiba, Hirohiko
Amemiya, Nobuyuki
Nitta, Kosaku
Tsuchiya, Ken
author_sort Yamazaki, Mayuko
collection PubMed
description A 41-year-old woman developed nephrotic syndrome at the age of 32 and was diagnosed with minimal change nephrotic syndrome based on a renal biopsy. Although remission was achieved with administration of prednisolone (PSL) and cyclosporine, the nephrotic syndrome recurred. She was also started on rituximab (RTX). She developed late-onset neutropenia after RTX treatment (R-LON) and improved 17 days later. Although the majority of R-LON cases undergo spontaneous remission, cases of death have been reported. This report is intended to warn about R-LON, since the use of RTX for adult-onset nephrotic syndrome is expected to increase in the future.
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spelling pubmed-64253562019-04-07 Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome Yamazaki, Mayuko Sugiura, Hidekazu Iwatani, Yosuke Kyoda, Mizuki Nokiba, Hirohiko Amemiya, Nobuyuki Nitta, Kosaku Tsuchiya, Ken Case Rep Nephrol Case Report A 41-year-old woman developed nephrotic syndrome at the age of 32 and was diagnosed with minimal change nephrotic syndrome based on a renal biopsy. Although remission was achieved with administration of prednisolone (PSL) and cyclosporine, the nephrotic syndrome recurred. She was also started on rituximab (RTX). She developed late-onset neutropenia after RTX treatment (R-LON) and improved 17 days later. Although the majority of R-LON cases undergo spontaneous remission, cases of death have been reported. This report is intended to warn about R-LON, since the use of RTX for adult-onset nephrotic syndrome is expected to increase in the future. Hindawi 2019-03-05 /pmc/articles/PMC6425356/ /pubmed/30956827 http://dx.doi.org/10.1155/2019/3580941 Text en Copyright © 2019 Mayuko Yamazaki et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yamazaki, Mayuko
Sugiura, Hidekazu
Iwatani, Yosuke
Kyoda, Mizuki
Nokiba, Hirohiko
Amemiya, Nobuyuki
Nitta, Kosaku
Tsuchiya, Ken
Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome
title Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome
title_full Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome
title_fullStr Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome
title_full_unstemmed Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome
title_short Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome
title_sort late-onset neutropenia after rituximab treatment for adult-onset nephrotic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425356/
https://www.ncbi.nlm.nih.gov/pubmed/30956827
http://dx.doi.org/10.1155/2019/3580941
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