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Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics

Implantable medical electronic devices are usually powered by batteries or capacitors, which have to be removed from the body after completing their function due to their non‐biodegradable property. Here, a fully bioabsorbable capacitor (BC) is developed for life‐time implantation. The BC has a symm...

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Detalles Bibliográficos
Autores principales: Li, Hu, Zhao, Chaochao, Wang, Xinxin, Meng, Jianping, Zou, Yang, Noreen, Sehrish, Zhao, Luming, Liu, Zhuo, Ouyang, Han, Tan, Puchuan, Yu, Min, Fan, Yubo, Wang, Zhong Lin, Li, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425441/
https://www.ncbi.nlm.nih.gov/pubmed/30937259
http://dx.doi.org/10.1002/advs.201801625
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author Li, Hu
Zhao, Chaochao
Wang, Xinxin
Meng, Jianping
Zou, Yang
Noreen, Sehrish
Zhao, Luming
Liu, Zhuo
Ouyang, Han
Tan, Puchuan
Yu, Min
Fan, Yubo
Wang, Zhong Lin
Li, Zhou
author_facet Li, Hu
Zhao, Chaochao
Wang, Xinxin
Meng, Jianping
Zou, Yang
Noreen, Sehrish
Zhao, Luming
Liu, Zhuo
Ouyang, Han
Tan, Puchuan
Yu, Min
Fan, Yubo
Wang, Zhong Lin
Li, Zhou
author_sort Li, Hu
collection PubMed
description Implantable medical electronic devices are usually powered by batteries or capacitors, which have to be removed from the body after completing their function due to their non‐biodegradable property. Here, a fully bioabsorbable capacitor (BC) is developed for life‐time implantation. The BC has a symmetrical layer‐by‐layer structure, including polylactic acid (PLA) supporting substrate, PLA nanopillar arrays, self‐assembled zinc oxide nanoporous layer, and polyvinyl alcohol/phosphate buffer solution (PVA/PBS) hydrogel. The as‐fabricated BC can not only work normally in air but also in a liquid environment, including PBS and the animal body. Long‐term normal work time is achieved to 30 days in PBS and 50 days in Sprague–Dawley (SD) rats. The work time of BC in the liquid environment is tunable from days to weeks by adopting different encapsulations along BC edges. Capacitance retention of 70% is achieved after 3000 cycles. Three BCs in series can light up 15 green light‐emitting diodes (LEDs) in vivo. Additionally, after completing its mission, the BC can be fully degraded in vivo and reabsorbed by a SD rat. Considering its performance, the developed BC has a great potential as a fully bioabsorbable power source for transient electronics and implantable medical devices.
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spelling pubmed-64254412019-04-01 Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics Li, Hu Zhao, Chaochao Wang, Xinxin Meng, Jianping Zou, Yang Noreen, Sehrish Zhao, Luming Liu, Zhuo Ouyang, Han Tan, Puchuan Yu, Min Fan, Yubo Wang, Zhong Lin Li, Zhou Adv Sci (Weinh) Communications Implantable medical electronic devices are usually powered by batteries or capacitors, which have to be removed from the body after completing their function due to their non‐biodegradable property. Here, a fully bioabsorbable capacitor (BC) is developed for life‐time implantation. The BC has a symmetrical layer‐by‐layer structure, including polylactic acid (PLA) supporting substrate, PLA nanopillar arrays, self‐assembled zinc oxide nanoporous layer, and polyvinyl alcohol/phosphate buffer solution (PVA/PBS) hydrogel. The as‐fabricated BC can not only work normally in air but also in a liquid environment, including PBS and the animal body. Long‐term normal work time is achieved to 30 days in PBS and 50 days in Sprague–Dawley (SD) rats. The work time of BC in the liquid environment is tunable from days to weeks by adopting different encapsulations along BC edges. Capacitance retention of 70% is achieved after 3000 cycles. Three BCs in series can light up 15 green light‐emitting diodes (LEDs) in vivo. Additionally, after completing its mission, the BC can be fully degraded in vivo and reabsorbed by a SD rat. Considering its performance, the developed BC has a great potential as a fully bioabsorbable power source for transient electronics and implantable medical devices. John Wiley and Sons Inc. 2019-01-22 /pmc/articles/PMC6425441/ /pubmed/30937259 http://dx.doi.org/10.1002/advs.201801625 Text en © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Li, Hu
Zhao, Chaochao
Wang, Xinxin
Meng, Jianping
Zou, Yang
Noreen, Sehrish
Zhao, Luming
Liu, Zhuo
Ouyang, Han
Tan, Puchuan
Yu, Min
Fan, Yubo
Wang, Zhong Lin
Li, Zhou
Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics
title Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics
title_full Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics
title_fullStr Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics
title_full_unstemmed Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics
title_short Fully Bioabsorbable Capacitor as an Energy Storage Unit for Implantable Medical Electronics
title_sort fully bioabsorbable capacitor as an energy storage unit for implantable medical electronics
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425441/
https://www.ncbi.nlm.nih.gov/pubmed/30937259
http://dx.doi.org/10.1002/advs.201801625
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