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Highly Soluble Drugs Directly Granulated by Water Dispersions of Insoluble Eudragit® Polymers as a Part of Hypromellose K100M Matrix Systems

The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis,...

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Detalles Bibliográficos
Autores principales:	Mašková, Eliška, Naiserová, Martina, Kubová, Kateřina, Mašek, Josef, Pavloková, Sylvie, Urbanová, Martina, Brus, Jiří, Vysloužil, Jakub, Vetchý, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425467/ https://www.ncbi.nlm.nih.gov/pubmed/30949510 http://dx.doi.org/10.1155/2019/8043415

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