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Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice

Herbal medicines have been used to prevent and cure diseases in eastern countries for thousands of years. In recent decades, these phytotherapies are becoming more and more popular in the West. As being nature-derived is the essential attribute of herbal medicines, people believe that taking them fo...

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Detalles Bibliográficos
Autores principales: Sun, Shi, Wang, Yifang, Wu, Ailing, Ding, Zhen, Liu, Xinguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425497/
https://www.ncbi.nlm.nih.gov/pubmed/30949215
http://dx.doi.org/10.1155/2019/1983780
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author Sun, Shi
Wang, Yifang
Wu, Ailing
Ding, Zhen
Liu, Xinguang
author_facet Sun, Shi
Wang, Yifang
Wu, Ailing
Ding, Zhen
Liu, Xinguang
author_sort Sun, Shi
collection PubMed
description Herbal medicines have been used to prevent and cure diseases in eastern countries for thousands of years. In recent decades, these phytotherapies are becoming more and more popular in the West. As being nature-derived is the essential attribute of herbal medicines, people believe that taking them for diseases treatment is safe enough and has no side-effects. However, the efficacy of herbal resourced compounds (HRC) depends on the multiple constituents absorbed in the body and their pharmacokinetics. Thus, many factors will influence the clinical practice of HRC, i.e., their absorption, distribution, metabolism, and excretion (ADME). Among these factors, herb-drug interaction has been widely discussed, as these compounds may share the same drug-metabolizing enzymes and drug transporters. Meanwhile there are many other potential factors that can also change the ADME of HRC, including herb pretreatment, herb-herb interactions, pathological status, gender, age of patient, and chemical and physical modification of certain ingredients. With the aim of ensuring the efficacy of HRC and minimizing their clinical risks, this review provides and discusses the influence factors and artificial improvement of the pharmacokinetics of HRC.
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spelling pubmed-64254972019-04-04 Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice Sun, Shi Wang, Yifang Wu, Ailing Ding, Zhen Liu, Xinguang Evid Based Complement Alternat Med Review Article Herbal medicines have been used to prevent and cure diseases in eastern countries for thousands of years. In recent decades, these phytotherapies are becoming more and more popular in the West. As being nature-derived is the essential attribute of herbal medicines, people believe that taking them for diseases treatment is safe enough and has no side-effects. However, the efficacy of herbal resourced compounds (HRC) depends on the multiple constituents absorbed in the body and their pharmacokinetics. Thus, many factors will influence the clinical practice of HRC, i.e., their absorption, distribution, metabolism, and excretion (ADME). Among these factors, herb-drug interaction has been widely discussed, as these compounds may share the same drug-metabolizing enzymes and drug transporters. Meanwhile there are many other potential factors that can also change the ADME of HRC, including herb pretreatment, herb-herb interactions, pathological status, gender, age of patient, and chemical and physical modification of certain ingredients. With the aim of ensuring the efficacy of HRC and minimizing their clinical risks, this review provides and discusses the influence factors and artificial improvement of the pharmacokinetics of HRC. Hindawi 2019-03-05 /pmc/articles/PMC6425497/ /pubmed/30949215 http://dx.doi.org/10.1155/2019/1983780 Text en Copyright © 2019 Shi Sun et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sun, Shi
Wang, Yifang
Wu, Ailing
Ding, Zhen
Liu, Xinguang
Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
title Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
title_full Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
title_fullStr Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
title_full_unstemmed Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
title_short Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
title_sort influence factors of the pharmacokinetics of herbal resourced compounds in clinical practice
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425497/
https://www.ncbi.nlm.nih.gov/pubmed/30949215
http://dx.doi.org/10.1155/2019/1983780
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