Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation

BACKGROUND: Orexins (hypocretins, Hcrt) A and B are GPCR-binding hypothalamic neuropeptides known to regulate sleep/wake states and feeding behavior. A few studies have shown that orexin A exhibits anti-inflammatory and neuroprotective properties, suggesting that it might provide therapeutic effects...

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Detalles Bibliográficos
Autores principales: Becquet, Laurine, Abad, Catalina, Leclercq, Mathilde, Miel, Camille, Jean, Laetitia, Riou, Gaëtan, Couvineau, Alain, Boyer, Olivier, Tan, Yossan-Var
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425555/
https://www.ncbi.nlm.nih.gov/pubmed/30894198
http://dx.doi.org/10.1186/s12974-019-1447-y

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