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Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel
OBJECTIVES: Voltage-gated Ca(2+) channels (VGCCs) are of central relevance in regulating Ca(2+) influx into living cells. The low-voltage activated (LVA) Ca(v)3 T-type Ca(2+) channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. T...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425560/ https://www.ncbi.nlm.nih.gov/pubmed/30894204 http://dx.doi.org/10.1186/s13104-019-4169-4 |
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author | Lundt, Andreas Henseler, Christina Wormuth, Carola Soos, Julien Seidel, Robin Müller, Ralf Arshaad, Muhammad Imran Broich, Karl Hescheler, Jürgen Sachinidis, Agapios Ehninger, Dan Papazoglou, Anna Weiergräber, Marco |
author_facet | Lundt, Andreas Henseler, Christina Wormuth, Carola Soos, Julien Seidel, Robin Müller, Ralf Arshaad, Muhammad Imran Broich, Karl Hescheler, Jürgen Sachinidis, Agapios Ehninger, Dan Papazoglou, Anna Weiergräber, Marco |
author_sort | Lundt, Andreas |
collection | PubMed |
description | OBJECTIVES: Voltage-gated Ca(2+) channels (VGCCs) are of central relevance in regulating Ca(2+) influx into living cells. The low-voltage activated (LVA) Ca(v)3 T-type Ca(2+) channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Ca(v)3.2 T-type Ca(2+) channels seem to be of special importance as qPCR revealed a steady increase in Ca(v)3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Ca(v)3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Ca(v)3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Ca(v)3.2(+/+), Ca(v)3.2(+/−) and Ca(v)3.2(−/−) mice from both genders which are of value for researchers who want to evaluate how Ca(v)3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies. DATA DESCRIPTION: Information presented here includes ABR data from age-matched female and male Ca(v)3.2(+/+), Ca(v)3.2(+/−) and Ca(v)3.2(−/−) mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis. |
format | Online Article Text |
id | pubmed-6425560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64255602019-03-29 Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel Lundt, Andreas Henseler, Christina Wormuth, Carola Soos, Julien Seidel, Robin Müller, Ralf Arshaad, Muhammad Imran Broich, Karl Hescheler, Jürgen Sachinidis, Agapios Ehninger, Dan Papazoglou, Anna Weiergräber, Marco BMC Res Notes Data Note Checks OBJECTIVES: Voltage-gated Ca(2+) channels (VGCCs) are of central relevance in regulating Ca(2+) influx into living cells. The low-voltage activated (LVA) Ca(v)3 T-type Ca(2+) channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Ca(v)3.2 T-type Ca(2+) channels seem to be of special importance as qPCR revealed a steady increase in Ca(v)3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Ca(v)3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Ca(v)3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Ca(v)3.2(+/+), Ca(v)3.2(+/−) and Ca(v)3.2(−/−) mice from both genders which are of value for researchers who want to evaluate how Ca(v)3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies. DATA DESCRIPTION: Information presented here includes ABR data from age-matched female and male Ca(v)3.2(+/+), Ca(v)3.2(+/−) and Ca(v)3.2(−/−) mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis. BioMed Central 2019-03-20 /pmc/articles/PMC6425560/ /pubmed/30894204 http://dx.doi.org/10.1186/s13104-019-4169-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Data Note Checks Lundt, Andreas Henseler, Christina Wormuth, Carola Soos, Julien Seidel, Robin Müller, Ralf Arshaad, Muhammad Imran Broich, Karl Hescheler, Jürgen Sachinidis, Agapios Ehninger, Dan Papazoglou, Anna Weiergräber, Marco Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel |
title | Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel |
title_full | Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel |
title_fullStr | Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel |
title_full_unstemmed | Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel |
title_short | Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca(v)3.2 T-type voltage-gated calcium channel |
title_sort | gender specific click and tone burst evoked abr datasets from mice lacking the ca(v)3.2 t-type voltage-gated calcium channel |
topic | Data Note Checks |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425560/ https://www.ncbi.nlm.nih.gov/pubmed/30894204 http://dx.doi.org/10.1186/s13104-019-4169-4 |
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