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Developing natural products as potential anti-biofilm agents
Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotics and antimicrobial agents. Quorum sensing (QS) is cell-to-cell communication mechanism, wh...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425673/ https://www.ncbi.nlm.nih.gov/pubmed/30936939 http://dx.doi.org/10.1186/s13020-019-0232-2 |
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author | Lu, Lan Hu, Wei Tian, Zeru Yuan, Dandan Yi, Guojuan Zhou, Yangyang Cheng, Qiang Zhu, Jie Li, Mingxing |
author_facet | Lu, Lan Hu, Wei Tian, Zeru Yuan, Dandan Yi, Guojuan Zhou, Yangyang Cheng, Qiang Zhu, Jie Li, Mingxing |
author_sort | Lu, Lan |
collection | PubMed |
description | Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotics and antimicrobial agents. Quorum sensing (QS) is cell-to-cell communication mechanism, which plays an important role in biofilm development and balances the environment when the bacteria density becomes high. Due to the prominent points of biofilms implicated in infectious disease and the spread of multi-drug resistance, it is urgent to discover new antibacterial agents that can regulate biofilm formation and development. Accumulated evidences demonstrated that natural products from plants had antimicrobial and chemo-preventive properties in modulation of biofilm formation in the last two decades. This review will summarize recent studies on the discovery of natural anti-biofilm agents from plants with clear-cut mechanisms or identified molecular addresses, as well as some herbs with unknown mechanisms or unidentified bioactive ingredients. We also focus on the progression of techniques on the extraction and identification of natural anti-biofilm substances. Besides, anti-biofilm therapeutics undergoing clinical trials are discussed. These newly discovered natural anti-biofilm agents are promising candidates which could provide novel strategies for biofilm-associated infections. |
format | Online Article Text |
id | pubmed-6425673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64256732019-04-01 Developing natural products as potential anti-biofilm agents Lu, Lan Hu, Wei Tian, Zeru Yuan, Dandan Yi, Guojuan Zhou, Yangyang Cheng, Qiang Zhu, Jie Li, Mingxing Chin Med Review Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotics and antimicrobial agents. Quorum sensing (QS) is cell-to-cell communication mechanism, which plays an important role in biofilm development and balances the environment when the bacteria density becomes high. Due to the prominent points of biofilms implicated in infectious disease and the spread of multi-drug resistance, it is urgent to discover new antibacterial agents that can regulate biofilm formation and development. Accumulated evidences demonstrated that natural products from plants had antimicrobial and chemo-preventive properties in modulation of biofilm formation in the last two decades. This review will summarize recent studies on the discovery of natural anti-biofilm agents from plants with clear-cut mechanisms or identified molecular addresses, as well as some herbs with unknown mechanisms or unidentified bioactive ingredients. We also focus on the progression of techniques on the extraction and identification of natural anti-biofilm substances. Besides, anti-biofilm therapeutics undergoing clinical trials are discussed. These newly discovered natural anti-biofilm agents are promising candidates which could provide novel strategies for biofilm-associated infections. BioMed Central 2019-03-20 /pmc/articles/PMC6425673/ /pubmed/30936939 http://dx.doi.org/10.1186/s13020-019-0232-2 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Lu, Lan Hu, Wei Tian, Zeru Yuan, Dandan Yi, Guojuan Zhou, Yangyang Cheng, Qiang Zhu, Jie Li, Mingxing Developing natural products as potential anti-biofilm agents |
title | Developing natural products as potential anti-biofilm agents |
title_full | Developing natural products as potential anti-biofilm agents |
title_fullStr | Developing natural products as potential anti-biofilm agents |
title_full_unstemmed | Developing natural products as potential anti-biofilm agents |
title_short | Developing natural products as potential anti-biofilm agents |
title_sort | developing natural products as potential anti-biofilm agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425673/ https://www.ncbi.nlm.nih.gov/pubmed/30936939 http://dx.doi.org/10.1186/s13020-019-0232-2 |
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