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The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients
BACKGROUND: ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142 (Q141K)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425717/ https://www.ncbi.nlm.nih.gov/pubmed/30894219 http://dx.doi.org/10.1186/s13075-019-1860-8 |