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The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients

BACKGROUND: ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142 (Q141K)...

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Detalles Bibliográficos
Autores principales:	Stiburkova, Blanka, Pavelcova, Katerina, Pavlikova, Marketa, Ješina, Pavel, Pavelka, Karel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425717/ https://www.ncbi.nlm.nih.gov/pubmed/30894219 http://dx.doi.org/10.1186/s13075-019-1860-8

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