The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

BACKGROUND: Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed cloves, hypothesised to act by S-thiolating reactive cysteines in target proteins....

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Detalles Bibliográficos
Autores principales: Kaschula, Catherine H., Tuveri, Rosanna, Ngarande, Ellen, Dzobo, Kevin, Barnett, Christopher, Kusza, Daniel A., Graham, Lisa M., Katz, Arieh A., Rafudeen, Mohamed Suhail, Parker, M. Iqbal, Hunter, Roger, Schäfer, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425727/
https://www.ncbi.nlm.nih.gov/pubmed/30894168
http://dx.doi.org/10.1186/s12885-019-5388-8

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