Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

Although endoplasmic reticulum (ER) chaperone binding to mutant proinsulin has been reported, the role of protein chaperones in the handling of wild-type proinsulin is underinvestigated. Here, we have explored the importance of glucose-regulated protein 94 (GRP94), a prominent ER chaperone known to...

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Detalles Bibliográficos
Autores principales: Ghiasi, Seyed Mojtaba, Dahlby, Tina, Hede Andersen, Caroline, Haataja, Leena, Petersen, Sólrun, Omar-Hmeadi, Muhmmad, Yang, Mingyu, Pihl, Celina, Bresson, Sophie Emilie, Khilji, Muhammad Saad, Klindt, Kristian, Cheta, Oana, Perone, Marcelo J., Tyrberg, Björn, Prats, Clara, Barg, Sebastian, Tengholm, Anders, Arvan, Peter, Mandrup-Poulsen, Thomas, Marzec, Michal Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2019
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425875/
https://www.ncbi.nlm.nih.gov/pubmed/30670477
http://dx.doi.org/10.2337/db18-0671

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