Cargando…

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

Recent immunotherapeutic approaches using adoptive cell therapy, or checkpoint blockade, have demonstrated the powerful anti-cancer potential of CD8 cytotoxic T-lymphocytes (CTL). While these approaches have shown great promise, they are only effective in some patients with some cancers. The potenti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galloway, Sarah A. E., Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E., Svane, Inge Marie, Donia, Marco, Cole, David K., Szomolay, Barbara, Rizkallah, Pierre, Sewell, Andrew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425991/ https://www.ncbi.nlm.nih.gov/pubmed/30930889 http://dx.doi.org/10.3389/fimmu.2019.00319

Ejemplares similares

Genome-wide CRISPR-Cas9 Screening Reveals Ubiquitous T cell Cancer Targeting via the monomorphic MHC class I related protein MR1
por: Crowther, Michael D., et al.
Publicado: (2020)

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen
por: Bianchi, Valentina, et al.
Publicado: (2016)

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
por: Rius, Cristina, et al.
Publicado: (2018)

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones
por: Theaker, Sarah M., et al.
Publicado: (2016)

Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells
por: Dolton, Garry, et al.
Publicado: (2018)

GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope
por: Whalley, Thomas, et al.
Publicado: (2020)

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig
por: Tungatt, Katie, et al.
Publicado: (2018)

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope
por: Dolton, Garry, et al.
Publicado: (2022)

CD4(+) T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
por: Greenshields-Watson, Alexander, et al.
Publicado: (2020)

αβ T cell receptors as predictors of health and disease
por: Attaf, Meriem, et al.
Publicado: (2015)

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
por: Cole, David K., et al.
Publicado: (2016)

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
por: MacLachlan, Bruce J., et al.
Publicado: (2019)

Structural Mechanism Underpinning Cross-reactivity of a CD8(+) T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase
por: Cole, David K., et al.
Publicado: (2017)

VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
por: Bagaev, Dmitry V, et al.
Publicado: (2020)

Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs
por: Tungatt, Katie, et al.
Publicado: (2015)

T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus
por: Bovay, Amandine, et al.
Publicado: (2017)

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry
por: Miles, John J., et al.
Publicado: (2018)

Metabolic Adaptation of Human CD4(+) and CD8(+) T-Cells to T-Cell Receptor-Mediated Stimulation
por: Jones, Nicholas, et al.
Publicado: (2017)

Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs
por: Hanson, W. Miachel, et al.
Publicado: (2016)

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
por: Laugel, Bruno, et al.
Publicado: (2016)

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope
por: Cole, David K., et al.
Publicado: (2017)

The T cell antigen receptor: the Swiss army knife of the immune system
por: Attaf, M, et al.
Publicado: (2015)

Real-world evidence to guide healthcare policies in oncology
por: Donia, Marco, et al.
Publicado: (2019)

B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?
por: Lauss, Martin, et al.
Publicado: (2022)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors
por: Szomolay, Barbara, et al.
Publicado: (2016)

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
por: MacLachlan, Bruce J., et al.
Publicado: (2017)

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection
por: Miles, John J., et al.
Publicado: (2010)

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting
por: Ekeruche-Makinde, Julia, et al.
Publicado: (2012)

Structural basis of human β-cell killing by CD8(+) T cells in Type 1 diabetes
por: Bulek, Anna M., et al.
Publicado: (2012)

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
por: Shugay, Mikhail, et al.
Publicado: (2018)

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01
por: Motozono, Chihiro, et al.
Publicado: (2014)

αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity
por: Attaf, Meriem, et al.
Publicado: (2016)

Analysis of Vδ1 T cells in clinical grade melanoma-infiltrating lymphocytes
por: Donia, Marco, et al.
Publicado: (2012)

Effects of Ipilimumab on expanded tumor infiltrating lymphocytes in patients with stage IV malignant melanoma
por: Bjørn, Jon, et al.
Publicado: (2013)

Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know
por: Bol, Kalijn Fredrike, et al.
Publicado: (2020)

Intratumoral T-cell and B-cell receptor architecture associates with distinct immune tumor microenvironment features and clinical outcomes of anti-PD-1/L1 immunotherapy
por: Schina, Aimilia, et al.
Publicado: (2023)

TCR/pMHC Optimized Protein crystallization Screen
por: Bulek, Anna M., et al.
Publicado: (2012)

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides
por: Madura, Florian, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_q8t1hh7c42u7nubt8g3ltta8ns