The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus

AIM: This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus. METHODS: The synergistic effects of the plants, as well as...

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Autores principales: Bahmani, Mahmoud, Taherikalani, Morovat, Khaksarian, Mojtaba, Rafieian-Kopaei, Mahmoud, Ashrafi, Behnam, Nazer, Mohammadreza, Soroush, Setareh, Abbasi, Naser, Rashidipour, Marzieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2019
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426173/
https://www.ncbi.nlm.nih.gov/pubmed/30906567
http://dx.doi.org/10.4155/fsoa-2018-0096
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author Bahmani, Mahmoud
Taherikalani, Morovat
Khaksarian, Mojtaba
Rafieian-Kopaei, Mahmoud
Ashrafi, Behnam
Nazer, Mohammadreza
Soroush, Setareh
Abbasi, Naser
Rashidipour, Marzieh
author_facet Bahmani, Mahmoud
Taherikalani, Morovat
Khaksarian, Mojtaba
Rafieian-Kopaei, Mahmoud
Ashrafi, Behnam
Nazer, Mohammadreza
Soroush, Setareh
Abbasi, Naser
Rashidipour, Marzieh
author_sort Bahmani, Mahmoud
collection PubMed
description AIM: This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus. METHODS: The synergistic effects of the plants, as well as carvacrol and hypericin, were examined using a checkered method against S. aureus (ATCC 12600). RESULTS: A fractional inhibitory concentration of 0.5 was obtained for combination of O. vulgare and H. perforatum and 0.49 for combination of the active ingredients carvacrol and hypericin, both of which indicated a synergistic effect. CONCLUSION: This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection. This study indicates that combination of the plants, as well as combination of carvacrol and hypericin, might be used as a new antibacterial strategy against S. aureus.
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spelling pubmed-64261732019-03-22 The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus Bahmani, Mahmoud Taherikalani, Morovat Khaksarian, Mojtaba Rafieian-Kopaei, Mahmoud Ashrafi, Behnam Nazer, Mohammadreza Soroush, Setareh Abbasi, Naser Rashidipour, Marzieh Future Sci OA Research Article AIM: This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus. METHODS: The synergistic effects of the plants, as well as carvacrol and hypericin, were examined using a checkered method against S. aureus (ATCC 12600). RESULTS: A fractional inhibitory concentration of 0.5 was obtained for combination of O. vulgare and H. perforatum and 0.49 for combination of the active ingredients carvacrol and hypericin, both of which indicated a synergistic effect. CONCLUSION: This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection. This study indicates that combination of the plants, as well as combination of carvacrol and hypericin, might be used as a new antibacterial strategy against S. aureus. Future Science Ltd 2019-01-31 /pmc/articles/PMC6426173/ /pubmed/30906567 http://dx.doi.org/10.4155/fsoa-2018-0096 Text en © 2019 Dr Setareh Soroush This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Bahmani, Mahmoud
Taherikalani, Morovat
Khaksarian, Mojtaba
Rafieian-Kopaei, Mahmoud
Ashrafi, Behnam
Nazer, Mohammadreza
Soroush, Setareh
Abbasi, Naser
Rashidipour, Marzieh
The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus
title The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus
title_full The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus
title_fullStr The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus
title_full_unstemmed The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus
title_short The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus
title_sort synergistic effect of hydroalcoholic extracts of origanum vulgare, hypericum perforatum and their active components carvacrol and hypericin against staphylococcus aureus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426173/
https://www.ncbi.nlm.nih.gov/pubmed/30906567
http://dx.doi.org/10.4155/fsoa-2018-0096
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