Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly, populations with the highest malaria intensity can be identified by the increased occurrence of endemic Burkitt Lymphoma (eBL), a pediatric cancer that...

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Detalles Bibliográficos
Autores principales: Gouveia, Mateus H., Bergen, Andrew W., Borda, Victor, Nunes, Kelly, Leal, Thiago P., Ogwang, Martin D., Yeboah, Edward D., Mensah, James E., Kinyera, Tobias, Otim, Isaac, Nabalende, Hadijah, Legason, Ismail D., Mpoloka, Sununguko Wata, Mokone, Gaonyadiwe George, Kerchan, Patrick, Bhatia, Kishor, Reynolds, Steven J., Birtwum, Richard B., Adjei, Andrew A., Tettey, Yao, Tay, Evelyn, Hoover, Robert, Pfeiffer, Ruth M., Biggar, Robert J., Goedert, James J., Prokunina-Olsson, Ludmila, Dean, Michael, Yeager, Meredith, Lima-Costa, M. Fernanda, Hsing, Ann W., Tishkoff, Sarah A., Chanock, Stephen J., Tarazona-Santos, Eduardo, Mbulaiteye, Sam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426263/
https://www.ncbi.nlm.nih.gov/pubmed/30849090
http://dx.doi.org/10.1371/journal.pgen.1008027

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