Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life

Extensive research in the past decade has brought mRNA closer to the clinical realization of its therapeutic potential. One common structural feature for all cellular messenger RNAs is a poly(A) tail, which can either be brought in cotranscriptionally via the DNA template (plasmid- or PCR-based) or...

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Detalles Bibliográficos
Autores principales: Trepotec, Zeljka, Geiger, Johannes, Plank, Christian, Aneja, Manish K., Rudolph, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426288/
https://www.ncbi.nlm.nih.gov/pubmed/30647100
http://dx.doi.org/10.1261/rna.069286.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426288/
https://www.ncbi.nlm.nih.gov/pubmed/30647100
http://dx.doi.org/10.1261/rna.069286.118

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