Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya

We evaluated outcomes of an HIV-1-testing intervention using rapid HIV tests followed by point-of-care Xpert Qual testing for HIV-1 RNA. Of 706 young urgent-care seeking participants evaluated, 24 (3.4%) had chronic HIV (antibody-positive), 3 (0.4%) acute HIV-1 (Qual-positive, antibody-negative), an...

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Autores principales: Sanders, Eduard J., Chirro, Oscar, Oduor, Clifford, Mangi, Juma, Wahome, Elizabeth, Price, Matthew A., Gelderblom, Hubert C., van der Elst, Elisabeth M., Graham, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426340/
https://www.ncbi.nlm.nih.gov/pubmed/30882493
http://dx.doi.org/10.1097/QAD.0000000000002110
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author Sanders, Eduard J.
Chirro, Oscar
Oduor, Clifford
Mangi, Juma
Wahome, Elizabeth
Price, Matthew A.
Gelderblom, Hubert C.
van der Elst, Elisabeth M.
Graham, Susan M.
author_facet Sanders, Eduard J.
Chirro, Oscar
Oduor, Clifford
Mangi, Juma
Wahome, Elizabeth
Price, Matthew A.
Gelderblom, Hubert C.
van der Elst, Elisabeth M.
Graham, Susan M.
author_sort Sanders, Eduard J.
collection PubMed
description We evaluated outcomes of an HIV-1-testing intervention using rapid HIV tests followed by point-of-care Xpert Qual testing for HIV-1 RNA. Of 706 young urgent-care seeking participants evaluated, 24 (3.4%) had chronic HIV (antibody-positive), 3 (0.4%) acute HIV-1 (Qual-positive, antibody-negative), and 3 (0.4%) early HIV-1 infection (Qual-positive, antibody-discordant). Overall, 21 (70.0%) diagnosed patients started antiretroviral therapy after a median of 4 days (range 0–71). HIV-1 RNA testing led to an increase in confirmed diagnoses by 25%.
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spelling pubmed-64263402019-04-15 Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya Sanders, Eduard J. Chirro, Oscar Oduor, Clifford Mangi, Juma Wahome, Elizabeth Price, Matthew A. Gelderblom, Hubert C. van der Elst, Elisabeth M. Graham, Susan M. AIDS Research Letter We evaluated outcomes of an HIV-1-testing intervention using rapid HIV tests followed by point-of-care Xpert Qual testing for HIV-1 RNA. Of 706 young urgent-care seeking participants evaluated, 24 (3.4%) had chronic HIV (antibody-positive), 3 (0.4%) acute HIV-1 (Qual-positive, antibody-negative), and 3 (0.4%) early HIV-1 infection (Qual-positive, antibody-discordant). Overall, 21 (70.0%) diagnosed patients started antiretroviral therapy after a median of 4 days (range 0–71). HIV-1 RNA testing led to an increase in confirmed diagnoses by 25%. Lippincott Williams & Wilkins 2019-04-01 2019-03-14 /pmc/articles/PMC6426340/ /pubmed/30882493 http://dx.doi.org/10.1097/QAD.0000000000002110 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Letter
Sanders, Eduard J.
Chirro, Oscar
Oduor, Clifford
Mangi, Juma
Wahome, Elizabeth
Price, Matthew A.
Gelderblom, Hubert C.
van der Elst, Elisabeth M.
Graham, Susan M.
Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya
title Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya
title_full Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya
title_fullStr Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya
title_full_unstemmed Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya
title_short Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya
title_sort point-of-care hiv rna testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in kenya
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426340/
https://www.ncbi.nlm.nih.gov/pubmed/30882493
http://dx.doi.org/10.1097/QAD.0000000000002110
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