Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

Stress granules (SGs) are non-membrane-bound RNA-protein granules that assemble through phase separation in response to cellular stress. Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotempora...

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Detalles Bibliográficos
Autores principales: Zhang, Peipei, Fan, Baochang, Yang, Peiguo, Temirov, Jamshid, Messing, James, Kim, Hong Joo, Taylor, J Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426440/
https://www.ncbi.nlm.nih.gov/pubmed/30893049
http://dx.doi.org/10.7554/eLife.39578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426440/
https://www.ncbi.nlm.nih.gov/pubmed/30893049
http://dx.doi.org/10.7554/eLife.39578

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