Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex

The question vis-à-vis the chemistry of phosphoryl group transfer catalyzed by protein kinases remains a major challenge. The neutron diffraction structure of the catalytic subunit of cAMP-dependent protein kinase (PKA-C) provides a more complete chemical portrait of key proton interactions at the a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerlits, Oksana, Weiss, Kevin L., Blakeley, Matthew P., Veglia, Gianluigi, Taylor, Susan S., Kovalevsky, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426457/
https://www.ncbi.nlm.nih.gov/pubmed/30906862
http://dx.doi.org/10.1126/sciadv.aav0482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426457/
https://www.ncbi.nlm.nih.gov/pubmed/30906862
http://dx.doi.org/10.1126/sciadv.aav0482

Ejemplares similares