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Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex

The question vis-à-vis the chemistry of phosphoryl group transfer catalyzed by protein kinases remains a major challenge. The neutron diffraction structure of the catalytic subunit of cAMP-dependent protein kinase (PKA-C) provides a more complete chemical portrait of key proton interactions at the a...

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Detalles Bibliográficos
Autores principales:	Gerlits, Oksana, Weiss, Kevin L., Blakeley, Matthew P., Veglia, Gianluigi, Taylor, Susan S., Kovalevsky, Andrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426457/ https://www.ncbi.nlm.nih.gov/pubmed/30906862 http://dx.doi.org/10.1126/sciadv.aav0482

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