Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.

Defective nuclear lamina protein lamin A is associated with premature aging. Casein kinase 2 (CK2) binds the nuclear lamina, and inhibiting CK2 activity induces cellular senescence in cancer cells. Thus, it is feasible that lamin A and CK2 may cooperate in the aging process. Nuclear CK2 localization...

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Detalles Bibliográficos
Autores principales: Ao, Ying, Zhang, Jie, Liu, Zuojun, Qian, Minxian, Li, Yao, Wu, Zhuping, Sun, Pengfei, Wu, Jie, Bei, Weixin, Wen, Junqu, Wu, Xuli, Li, Feng, Zhou, Zhongjun, Zhu, Wei-Guo, Liu, Baohua, Wang, Zimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426468/
https://www.ncbi.nlm.nih.gov/pubmed/30906869
http://dx.doi.org/10.1126/sciadv.aav5078

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