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Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis

To evaluate the clinical efficacy and safety of adenomyomectomy using “H” type incision combined with Mirena (LNG-IUS) in the treatment of adenomyosis. A total of 57 women with adenomyosis who underwent adenomyomectomy using “H” type incision combined with LNG-IUS were selected. Visual analog scale...

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Autores principales: Gao, Yanfei, Shan, Shuzhi, Zhao, Xin, Jiang, Jing, Li, Dongxiao, Shi, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426508/
https://www.ncbi.nlm.nih.gov/pubmed/30882624
http://dx.doi.org/10.1097/MD.0000000000014579
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author Gao, Yanfei
Shan, Shuzhi
Zhao, Xin
Jiang, Jing
Li, Dongxiao
Shi, Bin
author_facet Gao, Yanfei
Shan, Shuzhi
Zhao, Xin
Jiang, Jing
Li, Dongxiao
Shi, Bin
author_sort Gao, Yanfei
collection PubMed
description To evaluate the clinical efficacy and safety of adenomyomectomy using “H” type incision combined with Mirena (LNG-IUS) in the treatment of adenomyosis. A total of 57 women with adenomyosis who underwent adenomyomectomy using “H” type incision combined with LNG-IUS were selected. Visual analog scale (VAS), menstrual flow, uterine volume, serum CA125 levels and hemoglobin amounts were compared before and after the surgery. Meanwhile, postoperative pregnancy, adverse reactions, and recurrence were observed. VAS score, menstrual flow, uterine volume, and serum CA125 levels in 53 patients were significantly reduced after surgery (P < . 001). Moreover, statistical significances were obtained for VAS score at 13 and 6 months, menstrual flow at 1, 3, 6, 12, and 24 months, uterine volume at 1, 3, 6, 12, 24, and 36 months and CA125 levels at 1 and 3 months (P < .05). Of the 5 patients with fertility requirements, 1 became pregnant after IVF-ET, progressed to preterm, and delivered healthy twins. Among all related adverse reactions, amenorrhea was the most common (n = 20, 37.7%). There were no cases of LNG-IUS removal, ectopia, expulsion, and incarceration, except in 2 patients due to pregnancy, 1 due to uterine bleeding, and 1 due to Mirena perforation from incision of the uterine fundus. All patients showed no relapse. Adenomyomectomy using “H” type incision combined with Mirena constitutes a novel and effective conservative surgical procedure for adenomyosis treatment.
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spelling pubmed-64265082019-04-15 Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis Gao, Yanfei Shan, Shuzhi Zhao, Xin Jiang, Jing Li, Dongxiao Shi, Bin Medicine (Baltimore) Research Article To evaluate the clinical efficacy and safety of adenomyomectomy using “H” type incision combined with Mirena (LNG-IUS) in the treatment of adenomyosis. A total of 57 women with adenomyosis who underwent adenomyomectomy using “H” type incision combined with LNG-IUS were selected. Visual analog scale (VAS), menstrual flow, uterine volume, serum CA125 levels and hemoglobin amounts were compared before and after the surgery. Meanwhile, postoperative pregnancy, adverse reactions, and recurrence were observed. VAS score, menstrual flow, uterine volume, and serum CA125 levels in 53 patients were significantly reduced after surgery (P < . 001). Moreover, statistical significances were obtained for VAS score at 13 and 6 months, menstrual flow at 1, 3, 6, 12, and 24 months, uterine volume at 1, 3, 6, 12, 24, and 36 months and CA125 levels at 1 and 3 months (P < .05). Of the 5 patients with fertility requirements, 1 became pregnant after IVF-ET, progressed to preterm, and delivered healthy twins. Among all related adverse reactions, amenorrhea was the most common (n = 20, 37.7%). There were no cases of LNG-IUS removal, ectopia, expulsion, and incarceration, except in 2 patients due to pregnancy, 1 due to uterine bleeding, and 1 due to Mirena perforation from incision of the uterine fundus. All patients showed no relapse. Adenomyomectomy using “H” type incision combined with Mirena constitutes a novel and effective conservative surgical procedure for adenomyosis treatment. Wolters Kluwer Health 2019-03-15 /pmc/articles/PMC6426508/ /pubmed/30882624 http://dx.doi.org/10.1097/MD.0000000000014579 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/Licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Gao, Yanfei
Shan, Shuzhi
Zhao, Xin
Jiang, Jing
Li, Dongxiao
Shi, Bin
Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis
title Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis
title_full Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis
title_fullStr Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis
title_full_unstemmed Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis
title_short Clinical efficacy of adenomyomectomy using “H” type incision combined with Mirena in the treatment of adenomyosis
title_sort clinical efficacy of adenomyomectomy using “h” type incision combined with mirena in the treatment of adenomyosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426508/
https://www.ncbi.nlm.nih.gov/pubmed/30882624
http://dx.doi.org/10.1097/MD.0000000000014579
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