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The impact of marital status on survival in patients with surgically treated colon cancer

The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 and December 2015, a total of 925 patients with newly diagnosed colon cancer receiving curative resection were enrolled. The effect...

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Autores principales: Yang, Ching-Chieh, Cheng, Li-Chin, Lin, Yu-Wei, Wang, Shih-Chang, Ke, Te-Min, Huang, Chung-I., Su, Yu-Chieh, Tai, Ming-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426559/
https://www.ncbi.nlm.nih.gov/pubmed/30882684
http://dx.doi.org/10.1097/MD.0000000000014856
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author Yang, Ching-Chieh
Cheng, Li-Chin
Lin, Yu-Wei
Wang, Shih-Chang
Ke, Te-Min
Huang, Chung-I.
Su, Yu-Chieh
Tai, Ming-Hong
author_facet Yang, Ching-Chieh
Cheng, Li-Chin
Lin, Yu-Wei
Wang, Shih-Chang
Ke, Te-Min
Huang, Chung-I.
Su, Yu-Chieh
Tai, Ming-Hong
author_sort Yang, Ching-Chieh
collection PubMed
description The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 and December 2015, a total of 925 patients with newly diagnosed colon cancer receiving curative resection were enrolled. The effect of marital status on 5-year disease-specific survival (DSS) was calculated using Kaplan–Meier method, and was compared by log-rank tests. A Cox regression model was used to find significant independent variables and determine whether marriage had a survival benefit in patients with colon cancer, using stratified analysis. Among these patients, 749 (80.9%) were married, and 176 (19.1%) were unmarried, including 42 (4.5%) never-married, 42 (4.5%) divorced/separated, and 93 (10.1%) widowed. There was no significant difference between the married and unmarried groups in cancer stage or adjuvant treatment. Married patients had better 5-year DSS compared with unmarried patients (69.1% vs 55.9%, P < .001). Uni- and multivariate analyses also indicated that unmarried patients had worse 5-year DSS after adjusting for various confounders (adjusted HR [aHR], 1.66; 95% CI, 1.24–2.22). Further stratified analysis according to demographic variables revealed that unmarried status was a significant negative factor in patients with the following characteristics: age >65 years, female sex, well/moderately differentiated tumor, and advanced tumor-node-metastasis (TNM) stage disease (III–IV). Thus, marriage has a protective effect, and contributes to better survival in patients with surgically treated colon cancer. Additional social support for unmarried colon cancer patients may lead to improve outcomes.
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spelling pubmed-64265592019-04-15 The impact of marital status on survival in patients with surgically treated colon cancer Yang, Ching-Chieh Cheng, Li-Chin Lin, Yu-Wei Wang, Shih-Chang Ke, Te-Min Huang, Chung-I. Su, Yu-Chieh Tai, Ming-Hong Medicine (Baltimore) Research Article The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 and December 2015, a total of 925 patients with newly diagnosed colon cancer receiving curative resection were enrolled. The effect of marital status on 5-year disease-specific survival (DSS) was calculated using Kaplan–Meier method, and was compared by log-rank tests. A Cox regression model was used to find significant independent variables and determine whether marriage had a survival benefit in patients with colon cancer, using stratified analysis. Among these patients, 749 (80.9%) were married, and 176 (19.1%) were unmarried, including 42 (4.5%) never-married, 42 (4.5%) divorced/separated, and 93 (10.1%) widowed. There was no significant difference between the married and unmarried groups in cancer stage or adjuvant treatment. Married patients had better 5-year DSS compared with unmarried patients (69.1% vs 55.9%, P < .001). Uni- and multivariate analyses also indicated that unmarried patients had worse 5-year DSS after adjusting for various confounders (adjusted HR [aHR], 1.66; 95% CI, 1.24–2.22). Further stratified analysis according to demographic variables revealed that unmarried status was a significant negative factor in patients with the following characteristics: age >65 years, female sex, well/moderately differentiated tumor, and advanced tumor-node-metastasis (TNM) stage disease (III–IV). Thus, marriage has a protective effect, and contributes to better survival in patients with surgically treated colon cancer. Additional social support for unmarried colon cancer patients may lead to improve outcomes. Wolters Kluwer Health 2019-03-15 /pmc/articles/PMC6426559/ /pubmed/30882684 http://dx.doi.org/10.1097/MD.0000000000014856 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Yang, Ching-Chieh
Cheng, Li-Chin
Lin, Yu-Wei
Wang, Shih-Chang
Ke, Te-Min
Huang, Chung-I.
Su, Yu-Chieh
Tai, Ming-Hong
The impact of marital status on survival in patients with surgically treated colon cancer
title The impact of marital status on survival in patients with surgically treated colon cancer
title_full The impact of marital status on survival in patients with surgically treated colon cancer
title_fullStr The impact of marital status on survival in patients with surgically treated colon cancer
title_full_unstemmed The impact of marital status on survival in patients with surgically treated colon cancer
title_short The impact of marital status on survival in patients with surgically treated colon cancer
title_sort impact of marital status on survival in patients with surgically treated colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426559/
https://www.ncbi.nlm.nih.gov/pubmed/30882684
http://dx.doi.org/10.1097/MD.0000000000014856
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