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Villi development core-related gene expression associated with lung squamous cancer prognosis

Similarities between embryonic development and tumorigenesis are reflected in biological behavior and gene expression. Although the gene signature during development and the clinical phenotype of different cancers show certain correlation pattern, the correlation between early embryo development and...

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Autores principales: Yin, Liyuan, Wang, Yonggang, Ma, Guangzhi, Deng, Yunfu, Zhou, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426584/
https://www.ncbi.nlm.nih.gov/pubmed/30882635
http://dx.doi.org/10.1097/MD.0000000000014714
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author Yin, Liyuan
Wang, Yonggang
Ma, Guangzhi
Deng, Yunfu
Zhou, Qinghua
author_facet Yin, Liyuan
Wang, Yonggang
Ma, Guangzhi
Deng, Yunfu
Zhou, Qinghua
author_sort Yin, Liyuan
collection PubMed
description Similarities between embryonic development and tumorigenesis are reflected in biological behavior and gene expression. Although the gene signature during development and the clinical phenotype of different cancers show certain correlation pattern, the correlation between early embryo development and cancer remains largely unexplored. To compare the gene expression profile between development and cancer, our study analyzed the gene expression of chorionic villi samples at different gestational ages (6, 7, 8, 9, 10, 40 weeks) obtained from gene expression omnibus (GEO) datasets using correlation test. Then the villi development-related genes that gradually showed a positive correlation (upregulated) (n = 394) or negative correlation (downregulated) (n = 325) with time were used to construct protein-protein interaction (PPI) networks. Three subnetworks among the gradually upregulated genes and 3 subnetworks among the downregulated genes were identified using the molecular complex detection (MCODE) plugin in Cytoscape software. The most significant GO terms for villi-correlated genes were immune, inflammatory response and cell division. These gene clusters were also dysregulated in lung squamous cell carcinoma (SCC). Moreover the prognostic value of the gene clusters was then analyzed with TCGA lung SCC data, which showed 4 clusters that were associated with prognosis. Our results demonstrate the gene expression similarity between development and lung SCC and identified development-associated gene clusters that could contain prognostic information for lung SCC patients.
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spelling pubmed-64265842019-04-15 Villi development core-related gene expression associated with lung squamous cancer prognosis Yin, Liyuan Wang, Yonggang Ma, Guangzhi Deng, Yunfu Zhou, Qinghua Medicine (Baltimore) Research Article Similarities between embryonic development and tumorigenesis are reflected in biological behavior and gene expression. Although the gene signature during development and the clinical phenotype of different cancers show certain correlation pattern, the correlation between early embryo development and cancer remains largely unexplored. To compare the gene expression profile between development and cancer, our study analyzed the gene expression of chorionic villi samples at different gestational ages (6, 7, 8, 9, 10, 40 weeks) obtained from gene expression omnibus (GEO) datasets using correlation test. Then the villi development-related genes that gradually showed a positive correlation (upregulated) (n = 394) or negative correlation (downregulated) (n = 325) with time were used to construct protein-protein interaction (PPI) networks. Three subnetworks among the gradually upregulated genes and 3 subnetworks among the downregulated genes were identified using the molecular complex detection (MCODE) plugin in Cytoscape software. The most significant GO terms for villi-correlated genes were immune, inflammatory response and cell division. These gene clusters were also dysregulated in lung squamous cell carcinoma (SCC). Moreover the prognostic value of the gene clusters was then analyzed with TCGA lung SCC data, which showed 4 clusters that were associated with prognosis. Our results demonstrate the gene expression similarity between development and lung SCC and identified development-associated gene clusters that could contain prognostic information for lung SCC patients. Wolters Kluwer Health 2019-03-15 /pmc/articles/PMC6426584/ /pubmed/30882635 http://dx.doi.org/10.1097/MD.0000000000014714 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Yin, Liyuan
Wang, Yonggang
Ma, Guangzhi
Deng, Yunfu
Zhou, Qinghua
Villi development core-related gene expression associated with lung squamous cancer prognosis
title Villi development core-related gene expression associated with lung squamous cancer prognosis
title_full Villi development core-related gene expression associated with lung squamous cancer prognosis
title_fullStr Villi development core-related gene expression associated with lung squamous cancer prognosis
title_full_unstemmed Villi development core-related gene expression associated with lung squamous cancer prognosis
title_short Villi development core-related gene expression associated with lung squamous cancer prognosis
title_sort villi development core-related gene expression associated with lung squamous cancer prognosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426584/
https://www.ncbi.nlm.nih.gov/pubmed/30882635
http://dx.doi.org/10.1097/MD.0000000000014714
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