PKG-Modified TSC2 Regulates mTORC1 Activity to Counter Adverse Cardiac Stress

The mechanistic target of rapamycin complex-1 (mTORC1) coordinates regulation of growth, metabolism, protein synthesis, and autophagy(1). Its hyper-activation contributes to disease in many organs including the heart(1,2), though broad mTORC1 inhibition risks interference with its homeostatic roles....

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Detalles Bibliográficos
Autores principales: Ranek, Mark J., Kokkonen-Simon, Kristen M., Chen, Anna, Dunkerly-Eyring, Brittany L., Vera, Miguel Pinilla, Oeing, Christian U., Patel, Chirag H., Nakamura, Taishi, Zhu, Guangshuo, Bedja, Djahida, Sasaki, Masayuki, Holewinski, Ronald J., Van Eyk, Jennifer E., Powell, Jonathan D., Lee, Dong Ik, Kass, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426636/
https://www.ncbi.nlm.nih.gov/pubmed/30700906
http://dx.doi.org/10.1038/s41586-019-0895-y

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