Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish

Type IV mucolipidosis (ML-IV) is a neurodegenerative lysosome storage disorder caused by mutations in the MCOLN1 gene. However, the cellular and molecular bases underlying the neuronal phenotypes of ML-IV disease remain elusive. Using a forward genetic screening, we identified a zebrafish mutant, bi...

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Detalles Bibliográficos
Autores principales: Jin, Wan, Dai, Yimei, Li, Funing, Zhu, Lu, Huang, Zhibin, Liu, Wei, Li, Jianchao, Zhang, Mingjie, Du, Jiulin, Zhang, Wenqing, Wen, Zilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426713/
https://www.ncbi.nlm.nih.gov/pubmed/30897512
http://dx.doi.org/10.1016/j.isci.2019.02.031

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