PRL-3和RhoC在A549细胞中的表达及意义

BACKGROUND AND OBJECTIVE: The expression of phosphatase of regenerating liver-3 (PRL-3) is cor- related with Ras homologue C (RhoC) in non-small cell lung cancer (NSCLC), suggesting that they have interactions. The aim of this study is to investigate the functions of PRL-3 and RhoC in the migration...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2010
Materias:
短篇报道
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426730/
https://www.ncbi.nlm.nih.gov/pubmed/21159255
http://dx.doi.org/10.3779/j.issn.1009-3419.2010.12.15
Descripción
Sumario:BACKGROUND AND OBJECTIVE: The expression of phosphatase of regenerating liver-3 (PRL-3) is cor- related with Ras homologue C (RhoC) in non-small cell lung cancer (NSCLC), suggesting that they have interactions. The aim of this study is to investigate the functions of PRL-3 and RhoC in the migration of A549 cell and the potential mechanism of PRL-3 and RhoC in carcinogenesis and cancer development. METHODS: PRL-3Ab and RhoCAb were used to block the functions of PRL-3 and RhoC respectively. Wound healing assay was applied to detect the migration of A549 cell and the ex- pression levels of PRL-3 and RhoC were detected by RT-PCR. RESULTS: The migration of A549 cell decreased after blockage of PRL-3 and RhoC. The expression of RhoC decreased when PRL-3 was blocked without any changes on the expression of PRL-3. CONCLUSION: PRL-3, RhoC could increase cell migration in A549 cells.

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