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Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network

While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the...

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Autores principales: Schaefer, Franz, Benner, Laura, Borzych-Dużałka, Dagmara, Zaritsky, Joshua, Xu, Hong, Rees, Lesley, Antonio, Zenaida L., Serdaroglu, Erkin, Hooman, Nakysa, Patel, Hiren, Sever, Lale, Vondrak, Karel, Flynn, Joseph, Rébori, Anabella, Wong, William, Hölttä, Tuula, Yildirim, Zeynep Yuruk, Ranchin, Bruno, Grenda, Ryszard, Testa, Sara, Drożdz, Dorota, Szabo, Attila J., Eid, Loai, Basu, Biswanath, Vitkevic, Renata, Wong, Cynthia, Pottoore, Stephen J., Müller, Dominik, Dusunsel, Ruhan, Celedon, Claudia Gonzalez, Fila, Marc, Sartz, Lisa, Sander, Anja, Warady, Bradley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426856/
https://www.ncbi.nlm.nih.gov/pubmed/30894599
http://dx.doi.org/10.1038/s41598-018-36975-z
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author Schaefer, Franz
Benner, Laura
Borzych-Dużałka, Dagmara
Zaritsky, Joshua
Xu, Hong
Rees, Lesley
Antonio, Zenaida L.
Serdaroglu, Erkin
Hooman, Nakysa
Patel, Hiren
Sever, Lale
Vondrak, Karel
Flynn, Joseph
Rébori, Anabella
Wong, William
Hölttä, Tuula
Yildirim, Zeynep Yuruk
Ranchin, Bruno
Grenda, Ryszard
Testa, Sara
Drożdz, Dorota
Szabo, Attila J.
Eid, Loai
Basu, Biswanath
Vitkevic, Renata
Wong, Cynthia
Pottoore, Stephen J.
Müller, Dominik
Dusunsel, Ruhan
Celedon, Claudia Gonzalez
Fila, Marc
Sartz, Lisa
Sander, Anja
Warady, Bradley A.
author_facet Schaefer, Franz
Benner, Laura
Borzych-Dużałka, Dagmara
Zaritsky, Joshua
Xu, Hong
Rees, Lesley
Antonio, Zenaida L.
Serdaroglu, Erkin
Hooman, Nakysa
Patel, Hiren
Sever, Lale
Vondrak, Karel
Flynn, Joseph
Rébori, Anabella
Wong, William
Hölttä, Tuula
Yildirim, Zeynep Yuruk
Ranchin, Bruno
Grenda, Ryszard
Testa, Sara
Drożdz, Dorota
Szabo, Attila J.
Eid, Loai
Basu, Biswanath
Vitkevic, Renata
Wong, Cynthia
Pottoore, Stephen J.
Müller, Dominik
Dusunsel, Ruhan
Celedon, Claudia Gonzalez
Fila, Marc
Sartz, Lisa
Sander, Anja
Warady, Bradley A.
author_sort Schaefer, Franz
collection PubMed
description While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children.
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spelling pubmed-64268562019-03-27 Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network Schaefer, Franz Benner, Laura Borzych-Dużałka, Dagmara Zaritsky, Joshua Xu, Hong Rees, Lesley Antonio, Zenaida L. Serdaroglu, Erkin Hooman, Nakysa Patel, Hiren Sever, Lale Vondrak, Karel Flynn, Joseph Rébori, Anabella Wong, William Hölttä, Tuula Yildirim, Zeynep Yuruk Ranchin, Bruno Grenda, Ryszard Testa, Sara Drożdz, Dorota Szabo, Attila J. Eid, Loai Basu, Biswanath Vitkevic, Renata Wong, Cynthia Pottoore, Stephen J. Müller, Dominik Dusunsel, Ruhan Celedon, Claudia Gonzalez Fila, Marc Sartz, Lisa Sander, Anja Warady, Bradley A. Sci Rep Article While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children. Nature Publishing Group UK 2019-03-20 /pmc/articles/PMC6426856/ /pubmed/30894599 http://dx.doi.org/10.1038/s41598-018-36975-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Schaefer, Franz
Benner, Laura
Borzych-Dużałka, Dagmara
Zaritsky, Joshua
Xu, Hong
Rees, Lesley
Antonio, Zenaida L.
Serdaroglu, Erkin
Hooman, Nakysa
Patel, Hiren
Sever, Lale
Vondrak, Karel
Flynn, Joseph
Rébori, Anabella
Wong, William
Hölttä, Tuula
Yildirim, Zeynep Yuruk
Ranchin, Bruno
Grenda, Ryszard
Testa, Sara
Drożdz, Dorota
Szabo, Attila J.
Eid, Loai
Basu, Biswanath
Vitkevic, Renata
Wong, Cynthia
Pottoore, Stephen J.
Müller, Dominik
Dusunsel, Ruhan
Celedon, Claudia Gonzalez
Fila, Marc
Sartz, Lisa
Sander, Anja
Warady, Bradley A.
Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
title Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
title_full Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
title_fullStr Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
title_full_unstemmed Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
title_short Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
title_sort global variation of nutritional status in children undergoing chronic peritoneal dialysis: a longitudinal study of the international pediatric peritoneal dialysis network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426856/
https://www.ncbi.nlm.nih.gov/pubmed/30894599
http://dx.doi.org/10.1038/s41598-018-36975-z
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