Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model

Activation of liver X receptors (LXRs) by synthetic agonists was found to improve cognition in Alzheimer’s disease (AD) mice. However, these LXR agonists induce hypertriglyceridemia and hepatic steatosis, hampering their use in the clinic. We hypothesized that phytosterols as LXR agonists enhance co...

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Detalles Bibliográficos
Autores principales: Bogie, Jeroen, Hoeks, Cindy, Schepers, Melissa, Tiane, Assia, Cuypers, Ann, Leijten, Frank, Chintapakorn, Yupyn, Suttiyut, Thiti, Pornpakakul, Surachai, Struik, Dicky, Kerksiek, Anja, Liu, Hong-Bing, Hellings, Niels, Martinez-Martinez, Pilar, Jonker, Johan W., Dewachter, Ilse, Sijbrands, Eric, Walter, Jochen, Hendriks, Jerome, Groen, Albert, Staels, Bart, Lütjohann, Dieter, Vanmierlo, Tim, Mulder, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426980/
https://www.ncbi.nlm.nih.gov/pubmed/30894635
http://dx.doi.org/10.1038/s41598-019-41399-4

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