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Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo
Intracranial aneurysms are associated with disturbed velocity patterns, and chronic inflammation, but the relevance for these findings are currently unknown. Here, we show that (disturbed) shear stress induced by vortices is a sufficient condition to activate the endothelial NF-kB pathway, possibly...
Autores principales: | Baeriswyl, Daniel C., Prionisti, Ioanna, Peach, Tom, Tsolkas, Grigoris, Chooi, Kok Yean, Vardakis, John, Morel, Sandrine, Diagbouga, Mannekomba R., Bijlenga, Philippe, Cuhlmann, Simon, Evans, Paul, Kwak, Brenda R., Ventikos, Yiannis, Krams, Rob |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426999/ https://www.ncbi.nlm.nih.gov/pubmed/30894565 http://dx.doi.org/10.1038/s41598-019-40959-y |
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