Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo

Intracranial aneurysms are associated with disturbed velocity patterns, and chronic inflammation, but the relevance for these findings are currently unknown. Here, we show that (disturbed) shear stress induced by vortices is a sufficient condition to activate the endothelial NF-kB pathway, possibly...

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Detalles Bibliográficos
Autores principales: Baeriswyl, Daniel C., Prionisti, Ioanna, Peach, Tom, Tsolkas, Grigoris, Chooi, Kok Yean, Vardakis, John, Morel, Sandrine, Diagbouga, Mannekomba R., Bijlenga, Philippe, Cuhlmann, Simon, Evans, Paul, Kwak, Brenda R., Ventikos, Yiannis, Krams, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426999/
https://www.ncbi.nlm.nih.gov/pubmed/30894565
http://dx.doi.org/10.1038/s41598-019-40959-y

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