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Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)

Intensive research on photoacoustics (PA) for imaging of the living human body, including the skin, vessels, and tumors, has recently been conducted. We propose a PA measurement system based on a capacitive micromachined ultrasonic transducer (CMUT) with waterless coupling, short measurement time (&...

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Autores principales: Choi, Won Young, Kim, Young Hun, Jo, Hyeong Geun, Pyun, Joo Young, Kwon, Soo Won, Park, Kwan Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427691/
https://www.ncbi.nlm.nih.gov/pubmed/30813583
http://dx.doi.org/10.3390/s19050995
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author Choi, Won Young
Kim, Young Hun
Jo, Hyeong Geun
Pyun, Joo Young
Kwon, Soo Won
Park, Kwan Kyu
author_facet Choi, Won Young
Kim, Young Hun
Jo, Hyeong Geun
Pyun, Joo Young
Kwon, Soo Won
Park, Kwan Kyu
author_sort Choi, Won Young
collection PubMed
description Intensive research on photoacoustics (PA) for imaging of the living human body, including the skin, vessels, and tumors, has recently been conducted. We propose a PA measurement system based on a capacitive micromachined ultrasonic transducer (CMUT) with waterless coupling, short measurement time (<1 s), backward light irradiation, and a low-profile ultrasonic receiver unit (<1 cm). We fabricate a 64-element CMUT ring array with 6.2 mm diameter and 10.4 MHz center frequency in air, and 100% yield and uniform element response. To validate the PA tissue characterization, we employ pencil lead and red ink as solid and liquid models, respectively, and a living body to target moles and vessels. The system implements a near-field imaging system consisting of a 6 mm polydimethylsiloxane (PDMS) matching layer between the object and CMUT, which has a 3.7 MHz center frequency in PDMS. Experiments were performed in a waterless contact on the PDMS and the laser was irradiated with a 1 cm diameter. The experimental results show the feasibility of this near-field PA imaging system for position and depth detection of skin, mole, vessel cells, etc. Therefore, a system applicable to a low-profile compact biomedical device is presented.
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spelling pubmed-64276912019-04-15 Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT) Choi, Won Young Kim, Young Hun Jo, Hyeong Geun Pyun, Joo Young Kwon, Soo Won Park, Kwan Kyu Sensors (Basel) Article Intensive research on photoacoustics (PA) for imaging of the living human body, including the skin, vessels, and tumors, has recently been conducted. We propose a PA measurement system based on a capacitive micromachined ultrasonic transducer (CMUT) with waterless coupling, short measurement time (<1 s), backward light irradiation, and a low-profile ultrasonic receiver unit (<1 cm). We fabricate a 64-element CMUT ring array with 6.2 mm diameter and 10.4 MHz center frequency in air, and 100% yield and uniform element response. To validate the PA tissue characterization, we employ pencil lead and red ink as solid and liquid models, respectively, and a living body to target moles and vessels. The system implements a near-field imaging system consisting of a 6 mm polydimethylsiloxane (PDMS) matching layer between the object and CMUT, which has a 3.7 MHz center frequency in PDMS. Experiments were performed in a waterless contact on the PDMS and the laser was irradiated with a 1 cm diameter. The experimental results show the feasibility of this near-field PA imaging system for position and depth detection of skin, mole, vessel cells, etc. Therefore, a system applicable to a low-profile compact biomedical device is presented. MDPI 2019-02-26 /pmc/articles/PMC6427691/ /pubmed/30813583 http://dx.doi.org/10.3390/s19050995 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Won Young
Kim, Young Hun
Jo, Hyeong Geun
Pyun, Joo Young
Kwon, Soo Won
Park, Kwan Kyu
Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)
title Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)
title_full Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)
title_fullStr Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)
title_full_unstemmed Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)
title_short Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)
title_sort single-shot waterless low-profile photoacoustic system: near-field volumetric imaging in vivo for blood vessels based on capacitive micromachined ultrasonic transducer (cmut)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427691/
https://www.ncbi.nlm.nih.gov/pubmed/30813583
http://dx.doi.org/10.3390/s19050995
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