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Gait Patterns in Parkinson's Disease with or without Cognitive Impairment

BACKGROUND AND PURPOSE: Cognitive and gait disturbance are common symptoms in Parkinson's disease (PD). Although the relationship between cognitive impairment and gait dysfunction in PD has been suggested, specific gait patterns according to cognition are not fully demonstrated yet. Therefore,...

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Autores principales: Kim, Seung Min, Kim, Dae Hyun, Yang, YoungSoon, Ha, Sang Won, Han, Jeong Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dementia Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427969/
https://www.ncbi.nlm.nih.gov/pubmed/30906393
http://dx.doi.org/10.12779/dnd.2018.17.2.57
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author Kim, Seung Min
Kim, Dae Hyun
Yang, YoungSoon
Ha, Sang Won
Han, Jeong Ho
author_facet Kim, Seung Min
Kim, Dae Hyun
Yang, YoungSoon
Ha, Sang Won
Han, Jeong Ho
author_sort Kim, Seung Min
collection PubMed
description BACKGROUND AND PURPOSE: Cognitive and gait disturbance are common symptoms in Parkinson's disease (PD). Although the relationship between cognitive impairment and gait dysfunction in PD has been suggested, specific gait patterns according to cognition are not fully demonstrated yet. Therefore, the aim of this study was to investigate gait patterns in PD patients with or without cognitive impairment. METHODS: We studied 86 patients at an average of 4.8 years after diagnosis of PD. Cognitive impairment was defined as scoring 1.5 standard deviation below age- and education-specific means on the Korean version of the Mini-Mental State Examination (K-MMSE). Three-dimensional gait analysis was conducted for all patients and quantified gait parameters of temporal-spatial data were used. Relationships among cognition, demographic characteristics, clinical features, and gait pattern were evaluated. RESULTS: Cognitive impairment was observed in 41 (47.7%) patients. Compared to patients without cognitive impairment, patients with cognitive impairment displayed reduced gait speed, step length, and stride length. Among K-MMSE subcategories, “registration,” “attention/calculation,” and “visuospatial function” were significantly associated with speed, step length, and stride length. However, age, disease duration, Hoehn-Yahr (HY) stage, or Unified Parkinson's Disease Rating Scale (UPDRS) motor score was not significantly related to any gait analysis parameter. CONCLUSIONS: Our present study shows that cognitive impairment is associated with slow and short-stepped gait regardless of HY stage or UPDRS motor score, suggesting that cognitive impairment may serve as a surrogate marker of gait disturbance or fall in PD patients.
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spelling pubmed-64279692019-03-22 Gait Patterns in Parkinson's Disease with or without Cognitive Impairment Kim, Seung Min Kim, Dae Hyun Yang, YoungSoon Ha, Sang Won Han, Jeong Ho Dement Neurocogn Disord Original Article BACKGROUND AND PURPOSE: Cognitive and gait disturbance are common symptoms in Parkinson's disease (PD). Although the relationship between cognitive impairment and gait dysfunction in PD has been suggested, specific gait patterns according to cognition are not fully demonstrated yet. Therefore, the aim of this study was to investigate gait patterns in PD patients with or without cognitive impairment. METHODS: We studied 86 patients at an average of 4.8 years after diagnosis of PD. Cognitive impairment was defined as scoring 1.5 standard deviation below age- and education-specific means on the Korean version of the Mini-Mental State Examination (K-MMSE). Three-dimensional gait analysis was conducted for all patients and quantified gait parameters of temporal-spatial data were used. Relationships among cognition, demographic characteristics, clinical features, and gait pattern were evaluated. RESULTS: Cognitive impairment was observed in 41 (47.7%) patients. Compared to patients without cognitive impairment, patients with cognitive impairment displayed reduced gait speed, step length, and stride length. Among K-MMSE subcategories, “registration,” “attention/calculation,” and “visuospatial function” were significantly associated with speed, step length, and stride length. However, age, disease duration, Hoehn-Yahr (HY) stage, or Unified Parkinson's Disease Rating Scale (UPDRS) motor score was not significantly related to any gait analysis parameter. CONCLUSIONS: Our present study shows that cognitive impairment is associated with slow and short-stepped gait regardless of HY stage or UPDRS motor score, suggesting that cognitive impairment may serve as a surrogate marker of gait disturbance or fall in PD patients. Korean Dementia Association 2018-06 2018-07-24 /pmc/articles/PMC6427969/ /pubmed/30906393 http://dx.doi.org/10.12779/dnd.2018.17.2.57 Text en © 2018 Korean Dementia Association https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Seung Min
Kim, Dae Hyun
Yang, YoungSoon
Ha, Sang Won
Han, Jeong Ho
Gait Patterns in Parkinson's Disease with or without Cognitive Impairment
title Gait Patterns in Parkinson's Disease with or without Cognitive Impairment
title_full Gait Patterns in Parkinson's Disease with or without Cognitive Impairment
title_fullStr Gait Patterns in Parkinson's Disease with or without Cognitive Impairment
title_full_unstemmed Gait Patterns in Parkinson's Disease with or without Cognitive Impairment
title_short Gait Patterns in Parkinson's Disease with or without Cognitive Impairment
title_sort gait patterns in parkinson's disease with or without cognitive impairment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427969/
https://www.ncbi.nlm.nih.gov/pubmed/30906393
http://dx.doi.org/10.12779/dnd.2018.17.2.57
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