Cargando…
Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease
BACKGROUND AND PURPOSE: Although sleep disturbances are common and considered a major burden for patients with Alzheimer's disease (AD), the fundamental mechanisms underlying the development and maintenance of sleep disturbance in AD patients have yet to be elucidated. The aim of this study was...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dementia Association
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427985/ https://www.ncbi.nlm.nih.gov/pubmed/30906374 http://dx.doi.org/10.12779/dnd.2017.16.3.72 |
_version_ | 1783405331462750208 |
---|---|
author | Im, Jooyeon J. Jeong, Hyeonseok S. Park, Jong-Sik Na, Seung-Hee Chung, Yong-An Yang, YoungSoon Song, In-Uk |
author_facet | Im, Jooyeon J. Jeong, Hyeonseok S. Park, Jong-Sik Na, Seung-Hee Chung, Yong-An Yang, YoungSoon Song, In-Uk |
author_sort | Im, Jooyeon J. |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Although sleep disturbances are common and considered a major burden for patients with Alzheimer's disease (AD), the fundamental mechanisms underlying the development and maintenance of sleep disturbance in AD patients have yet to be elucidated. The aim of this study was to examine the correlation between regional cerebral blood flow (rCBF) and sleep disturbance in AD patients using technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT). METHODS: A total of 140 AD patients were included in this cross-sectional study. Seventy patients were assigned to the AD with sleep loss (SL) group and the rest were assigned to the AD without SL group. SL was measured using the sleep subscale of the Neuropsychiatric Inventory. A whole-brain voxel-wise analysis of brain SPECT data was conducted to compare the rCBF between the two groups. RESULTS: The two groups did not differ in demographic characteristics, severity of dementia, general cognitive function, and neuropsychiatric symptoms, with the exception of sleep disturbances. The SPECT imaging analysis displayed decreased perfusion in the bilateral inferior frontal gyrus, bilateral temporal pole, and right precentral gyrus in the AD patients with SL group compared with the AD patients without SL group. It also revealed increased perfusion in the right precuneus, right occipital pole, and left middle occipital gyrus in the AD with SL group compared with the AD without SL group. CONCLUSIONS: The AD patients who experienced sleep disturbance had notably decreased perfusion in the frontal and temporal lobes and increased rCBF in the parietal and occipital regions. The findings of this study suggest that functional alterations in these brain areas may be the underlying neural correlates of sleep disturbance in AD patients. |
format | Online Article Text |
id | pubmed-6427985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Dementia Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-64279852019-03-22 Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease Im, Jooyeon J. Jeong, Hyeonseok S. Park, Jong-Sik Na, Seung-Hee Chung, Yong-An Yang, YoungSoon Song, In-Uk Dement Neurocogn Disord Original Article BACKGROUND AND PURPOSE: Although sleep disturbances are common and considered a major burden for patients with Alzheimer's disease (AD), the fundamental mechanisms underlying the development and maintenance of sleep disturbance in AD patients have yet to be elucidated. The aim of this study was to examine the correlation between regional cerebral blood flow (rCBF) and sleep disturbance in AD patients using technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT). METHODS: A total of 140 AD patients were included in this cross-sectional study. Seventy patients were assigned to the AD with sleep loss (SL) group and the rest were assigned to the AD without SL group. SL was measured using the sleep subscale of the Neuropsychiatric Inventory. A whole-brain voxel-wise analysis of brain SPECT data was conducted to compare the rCBF between the two groups. RESULTS: The two groups did not differ in demographic characteristics, severity of dementia, general cognitive function, and neuropsychiatric symptoms, with the exception of sleep disturbances. The SPECT imaging analysis displayed decreased perfusion in the bilateral inferior frontal gyrus, bilateral temporal pole, and right precentral gyrus in the AD patients with SL group compared with the AD patients without SL group. It also revealed increased perfusion in the right precuneus, right occipital pole, and left middle occipital gyrus in the AD with SL group compared with the AD without SL group. CONCLUSIONS: The AD patients who experienced sleep disturbance had notably decreased perfusion in the frontal and temporal lobes and increased rCBF in the parietal and occipital regions. The findings of this study suggest that functional alterations in these brain areas may be the underlying neural correlates of sleep disturbance in AD patients. Korean Dementia Association 2017-09 2017-09-30 /pmc/articles/PMC6427985/ /pubmed/30906374 http://dx.doi.org/10.12779/dnd.2017.16.3.72 Text en © 2017 Korean Dementia Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Im, Jooyeon J. Jeong, Hyeonseok S. Park, Jong-Sik Na, Seung-Hee Chung, Yong-An Yang, YoungSoon Song, In-Uk Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease |
title | Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease |
title_full | Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease |
title_fullStr | Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease |
title_full_unstemmed | Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease |
title_short | Associations between Brain Perfusion and Sleep Disturbance in Patients with Alzheimer's Disease |
title_sort | associations between brain perfusion and sleep disturbance in patients with alzheimer's disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427985/ https://www.ncbi.nlm.nih.gov/pubmed/30906374 http://dx.doi.org/10.12779/dnd.2017.16.3.72 |
work_keys_str_mv | AT imjooyeonj associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease AT jeonghyeonseoks associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease AT parkjongsik associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease AT naseunghee associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease AT chungyongan associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease AT yangyoungsoon associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease AT songinuk associationsbetweenbrainperfusionandsleepdisturbanceinpatientswithalzheimersdisease |