Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient

BACKGROUND: Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia. CASE REPORT: We report a c...

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Detalles Bibliográficos
Autores principales: Kim, Yong Sung, Kim, Seung Jae, Lee, Jongmin, Kim, Hee-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dementia Association 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427994/
https://www.ncbi.nlm.nih.gov/pubmed/30906390
http://dx.doi.org/10.12779/dnd.2018.17.1.37
Descripción
Sumario:BACKGROUND: Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia. CASE REPORT: We report a case of MSA-cerebellum subtype associated with emergence of irreversible explosive speech following olanzapine therapy. CONCLUSIONS: Further investigation into speech problems in MSA according to subtype and disease severity is needed, and side effects of olanzapine therapy should also be considered.

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