Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient

BACKGROUND: Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia. CASE REPORT: We report a c...

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Autores principales: Kim, Yong Sung, Kim, Seung Jae, Lee, Jongmin, Kim, Hee-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dementia Association 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427994/
https://www.ncbi.nlm.nih.gov/pubmed/30906390
http://dx.doi.org/10.12779/dnd.2018.17.1.37
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author Kim, Yong Sung
Kim, Seung Jae
Lee, Jongmin
Kim, Hee-Jin
author_facet Kim, Yong Sung
Kim, Seung Jae
Lee, Jongmin
Kim, Hee-Jin
author_sort Kim, Yong Sung
collection PubMed
description BACKGROUND: Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia. CASE REPORT: We report a case of MSA-cerebellum subtype associated with emergence of irreversible explosive speech following olanzapine therapy. CONCLUSIONS: Further investigation into speech problems in MSA according to subtype and disease severity is needed, and side effects of olanzapine therapy should also be considered.
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spelling pubmed-64279942019-03-22 Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient Kim, Yong Sung Kim, Seung Jae Lee, Jongmin Kim, Hee-Jin Dement Neurocogn Disord Case Report BACKGROUND: Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia. CASE REPORT: We report a case of MSA-cerebellum subtype associated with emergence of irreversible explosive speech following olanzapine therapy. CONCLUSIONS: Further investigation into speech problems in MSA according to subtype and disease severity is needed, and side effects of olanzapine therapy should also be considered. Korean Dementia Association 2018-03 2018-03-26 /pmc/articles/PMC6427994/ /pubmed/30906390 http://dx.doi.org/10.12779/dnd.2018.17.1.37 Text en © 2018 Korean Dementia Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Yong Sung
Kim, Seung Jae
Lee, Jongmin
Kim, Hee-Jin
Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
title Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
title_full Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
title_fullStr Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
title_full_unstemmed Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
title_short Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
title_sort emerging of explosive speech after olanzapine in multiple system atrophy patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427994/
https://www.ncbi.nlm.nih.gov/pubmed/30906390
http://dx.doi.org/10.12779/dnd.2018.17.1.37
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AT leejongmin emergingofexplosivespeechafterolanzapineinmultiplesystematrophypatient
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