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Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia

The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We...

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Autores principales: Grzesiak, Katarzyna, Rył, Aleksandra, Ratajczak, Weronika, Stachowska, Ewa, Rotter, Iwona, Słojewski, Marcin, Sipak, Olimpia, Walczakiewicz, Kinga, Laszczyńska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428091/
https://www.ncbi.nlm.nih.gov/pubmed/30867336
http://dx.doi.org/10.18632/aging.101850
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author Grzesiak, Katarzyna
Rył, Aleksandra
Ratajczak, Weronika
Stachowska, Ewa
Rotter, Iwona
Słojewski, Marcin
Sipak, Olimpia
Walczakiewicz, Kinga
Laszczyńska, Maria
author_facet Grzesiak, Katarzyna
Rył, Aleksandra
Ratajczak, Weronika
Stachowska, Ewa
Rotter, Iwona
Słojewski, Marcin
Sipak, Olimpia
Walczakiewicz, Kinga
Laszczyńska, Maria
author_sort Grzesiak, Katarzyna
collection PubMed
description The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. The patients differed in terms of hormone levels, but only the differences in SHBG and IGF-1 levels were statistically significant. Analysis of the levels of polysaturated fatty acids in BPH patients showed that MetS contributed to changes in the levels of these acids. We also analyzed the relationship between the levels of fatty acids and diagnostic parameters for MetS. Particular abnormalities were associated with single changes in the levels of fatty acids. In the diabetic patients, changes in the levels of pentadecanoic acid, heptadecanoic acid and cis-11-eicosenoic acid were demonstrated. Our findings indicate the necessity for further investigation concerning the levels of fatty acids and their impact on the development of MetS, as well as the course and clinical picture of BPH.
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spelling pubmed-64280912019-03-26 Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia Grzesiak, Katarzyna Rył, Aleksandra Ratajczak, Weronika Stachowska, Ewa Rotter, Iwona Słojewski, Marcin Sipak, Olimpia Walczakiewicz, Kinga Laszczyńska, Maria Aging (Albany NY) Research Paper The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. The patients differed in terms of hormone levels, but only the differences in SHBG and IGF-1 levels were statistically significant. Analysis of the levels of polysaturated fatty acids in BPH patients showed that MetS contributed to changes in the levels of these acids. We also analyzed the relationship between the levels of fatty acids and diagnostic parameters for MetS. Particular abnormalities were associated with single changes in the levels of fatty acids. In the diabetic patients, changes in the levels of pentadecanoic acid, heptadecanoic acid and cis-11-eicosenoic acid were demonstrated. Our findings indicate the necessity for further investigation concerning the levels of fatty acids and their impact on the development of MetS, as well as the course and clinical picture of BPH. Impact Journals 2019-03-13 /pmc/articles/PMC6428091/ /pubmed/30867336 http://dx.doi.org/10.18632/aging.101850 Text en Copyright © 2019 Grzesiak et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Grzesiak, Katarzyna
Rył, Aleksandra
Ratajczak, Weronika
Stachowska, Ewa
Rotter, Iwona
Słojewski, Marcin
Sipak, Olimpia
Walczakiewicz, Kinga
Laszczyńska, Maria
Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
title Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
title_full Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
title_fullStr Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
title_full_unstemmed Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
title_short Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
title_sort influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428091/
https://www.ncbi.nlm.nih.gov/pubmed/30867336
http://dx.doi.org/10.18632/aging.101850
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