Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer

Lung cancer is the leading cause of cancer-related death, and NSCLC constitutes nearly 85%–90% of all cases. The IRS proteins function as adaptors and transmit signals from multiple receptors. Upon binding of insulin to the insulin receptor (IR), IRS1 is phosphorylated at several YXXM motifs creatin...

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Detalles Bibliográficos
Autores principales: Gorgisen, Gokhan, Hapil, Fatma Zehra, Yilmaz, Ozlem, Cetin, Zafer, Pehlivanoglu, Suray, Ozbudak, Irem Hicran, Erdogan, Abdullah, Ozes, Osman Nidai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428125/
https://www.ncbi.nlm.nih.gov/pubmed/30807634
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0307

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