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Does the expression of the ACVR2A gene affect the development of colorectal cancer?

Colorectal cancer has become a serious problem, especially in highly developed countries. As reported by the World Health Organization, the number of colon cancer cases in the world in 2012 amounted to 1.36 million. It is the second most common cancer in females (614,000 cases, 9.2% of the total) an...

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Autores principales: Wodziński, Damian, Wosiak, Agnieszka, Pietrzak, Jacek, Świechowski, Rafał, Jeleń, Agnieszka, Balcerczak, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428132/
https://www.ncbi.nlm.nih.gov/pubmed/30856244
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0332
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author Wodziński, Damian
Wosiak, Agnieszka
Pietrzak, Jacek
Świechowski, Rafał
Jeleń, Agnieszka
Balcerczak, Ewa
author_facet Wodziński, Damian
Wosiak, Agnieszka
Pietrzak, Jacek
Świechowski, Rafał
Jeleń, Agnieszka
Balcerczak, Ewa
author_sort Wodziński, Damian
collection PubMed
description Colorectal cancer has become a serious problem, especially in highly developed countries. As reported by the World Health Organization, the number of colon cancer cases in the world in 2012 amounted to 1.36 million. It is the second most common cancer in females (614,000 cases, 9.2% of the total) and the third in males (746,000 cases, 10.0% of the total) worldwide. It is believed that TGFβ pathway elements are involved in the pathogenesis of colorectal cancer. This study assessed one of these elements, the ACVR2A gene. Qualitative and quantitative analyses of the ACVR2A gene in 84 patients with colorectal cancer was performed. There was no statistically significant association between ACVR2A gene expression and age, gender, histological type, grading of tumor, vascular invasion, and presence of lymphocytes in tumor tissue. No association was observed between the ACVR2A gene expression level and the presence of metastases in regional lymph nodes and distant metastases. In this study, larger tumors (T3 and T4) were characterized by higher ACVR2A expression compared to smaller tumors (T1 and T2). This may indicate an association between ACVR2A expression and the severity of pathological changes in the tumor growth process.
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spelling pubmed-64281322019-04-16 Does the expression of the ACVR2A gene affect the development of colorectal cancer? Wodziński, Damian Wosiak, Agnieszka Pietrzak, Jacek Świechowski, Rafał Jeleń, Agnieszka Balcerczak, Ewa Genet Mol Biol Human and Medical Genetics Colorectal cancer has become a serious problem, especially in highly developed countries. As reported by the World Health Organization, the number of colon cancer cases in the world in 2012 amounted to 1.36 million. It is the second most common cancer in females (614,000 cases, 9.2% of the total) and the third in males (746,000 cases, 10.0% of the total) worldwide. It is believed that TGFβ pathway elements are involved in the pathogenesis of colorectal cancer. This study assessed one of these elements, the ACVR2A gene. Qualitative and quantitative analyses of the ACVR2A gene in 84 patients with colorectal cancer was performed. There was no statistically significant association between ACVR2A gene expression and age, gender, histological type, grading of tumor, vascular invasion, and presence of lymphocytes in tumor tissue. No association was observed between the ACVR2A gene expression level and the presence of metastases in regional lymph nodes and distant metastases. In this study, larger tumors (T3 and T4) were characterized by higher ACVR2A expression compared to smaller tumors (T1 and T2). This may indicate an association between ACVR2A expression and the severity of pathological changes in the tumor growth process. Sociedade Brasileira de Genética 2019-03-11 2019 /pmc/articles/PMC6428132/ /pubmed/30856244 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0332 Text en Copyright © 2018, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
Wodziński, Damian
Wosiak, Agnieszka
Pietrzak, Jacek
Świechowski, Rafał
Jeleń, Agnieszka
Balcerczak, Ewa
Does the expression of the ACVR2A gene affect the development of colorectal cancer?
title Does the expression of the ACVR2A gene affect the development of colorectal cancer?
title_full Does the expression of the ACVR2A gene affect the development of colorectal cancer?
title_fullStr Does the expression of the ACVR2A gene affect the development of colorectal cancer?
title_full_unstemmed Does the expression of the ACVR2A gene affect the development of colorectal cancer?
title_short Does the expression of the ACVR2A gene affect the development of colorectal cancer?
title_sort does the expression of the acvr2a gene affect the development of colorectal cancer?
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428132/
https://www.ncbi.nlm.nih.gov/pubmed/30856244
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0332
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