Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism

Mitochondria are potential therapeutic targets for anticancer drugs. A series of mitochondrion-targeted monofunctional platinum complexes, [Pt(ortho-PPh(3)CH(2)Py)(NH(3))(2)Cl](NO(3))(2) (OPT), [Pt(meta-PPh(3)CH(2)Py)(NH(3))(2)Cl](NO(3))(2) (MPT), and [Pt(para-PPh(3)CH(2)Py)(NH(3))(2)Cl](NO(3))(2) (...

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Detalles Bibliográficos
Autores principales: Zhu, Zhenzhu, Wang, Zenghui, Zhang, Changli, Wang, Yanjun, Zhang, Hongmei, Gan, Zhenji, Guo, Zijian, Wang, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428137/
https://www.ncbi.nlm.nih.gov/pubmed/30996891
http://dx.doi.org/10.1039/c8sc04871a

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