Amelioration of Huntington’s disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington’s disease monkeys

Huntington’s disease (HD) is a devastating monogenic, dominant, hereditary, neurodegenerative disease. HD is caused by the expansion of CAG repeats in exon 1 of the huntingtin (HTT) gene, IT15, resulting in an expanded polyglutamine (polyQ) residue in the N-terminus of the HTT protein. HD is charact...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, In Ki, Yang, Bo, Forest, Craig, Qian, Lu, Chan, Anthony W. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428250/
https://www.ncbi.nlm.nih.gov/pubmed/30897183
http://dx.doi.org/10.1371/journal.pone.0214156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428250/
https://www.ncbi.nlm.nih.gov/pubmed/30897183
http://dx.doi.org/10.1371/journal.pone.0214156

Ejemplares similares