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Amelioration of Huntington’s disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington’s disease monkeys

Huntington’s disease (HD) is a devastating monogenic, dominant, hereditary, neurodegenerative disease. HD is caused by the expansion of CAG repeats in exon 1 of the huntingtin (HTT) gene, IT15, resulting in an expanded polyglutamine (polyQ) residue in the N-terminus of the HTT protein. HD is charact...

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Detalles Bibliográficos
Autores principales:	Cho, In Ki, Yang, Bo, Forest, Craig, Qian, Lu, Chan, Anthony W. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428250/ https://www.ncbi.nlm.nih.gov/pubmed/30897183 http://dx.doi.org/10.1371/journal.pone.0214156

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