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Pre-existing antibodies to candidate gene therapy vectors (adeno-associated vector serotypes) in domestic cats

Adeno-associated virus (AAV) vectors represent promising candidates for gene therapy; however, pre-existing neutralizing antibodies (NAb) may reduce AAV vector delivery efficiency. In this study, the presence of AAV NAb was investigated in cats, which serve as a larger and outbred animal model for t...

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Detalles Bibliográficos
Autores principales:	Li, Pengfei, Boenzli, Eva, Hofmann-Lehmann, Regina, Helfer-Hungerbuehler, A. Katrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428272/ https://www.ncbi.nlm.nih.gov/pubmed/30897117 http://dx.doi.org/10.1371/journal.pone.0212811

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