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Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats
Testosterone is associated with an increased risk of coronary heart disease. This study evaluated cardiac remodeling 60 days after myocardial infarction (MI) in rats with testosterone deficiency. One week after castration, the animals underwent myocardial infarction. Rats were divided into four grou...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428328/ https://www.ncbi.nlm.nih.gov/pubmed/30897106 http://dx.doi.org/10.1371/journal.pone.0213351 |
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author | Fernandes Corrêa, Rafaela de Araujo Ribeiro Júnior, Rogério Faustino Mendes, Sara Bianca Oliveira dos Santos, Priscila Mendonça da Silva, Miracle Vitória Albino Silva, Daniel Ferron Biral, Igor Peixoto de Batista, Priscila Rossi Vassallo, Dalton Valentim Bittencourt, Athelson Stefanon Stefanon, Ivanita Fernandes, Aurélia Araújo |
author_facet | Fernandes Corrêa, Rafaela de Araujo Ribeiro Júnior, Rogério Faustino Mendes, Sara Bianca Oliveira dos Santos, Priscila Mendonça da Silva, Miracle Vitória Albino Silva, Daniel Ferron Biral, Igor Peixoto de Batista, Priscila Rossi Vassallo, Dalton Valentim Bittencourt, Athelson Stefanon Stefanon, Ivanita Fernandes, Aurélia Araújo |
author_sort | Fernandes Corrêa, Rafaela de Araujo |
collection | PubMed |
description | Testosterone is associated with an increased risk of coronary heart disease. This study evaluated cardiac remodeling 60 days after myocardial infarction (MI) in rats with testosterone deficiency. One week after castration, the animals underwent myocardial infarction. Rats were divided into four groups: orchidectomized (OCT); orchidectomized and infarcted (OCT+MI), MI and control (Sham). The myocyte cross-sectional area and the papillary muscle contractility were evaluated 8 weeks after MI. The coronary bed was perfused with Biodur E20 resin to evaluate the neovascularization after MI. Data were expressed as mean ± SEM followed by ANOVA. Castration reduced myocyte hypertrophy when compared to Sham and myocardial infarction alone as well as preserved the contraction force and activation time after myocardial infarction. After beta-adrenergic stimulation, activation and relaxation kinetics were less impaired in the OCT+MI group than in the MI group. Contraction force was preserved in the OCT+MI group after beta-adrenergic stimulation. Multiple scanning electronic microscope images were obtained to characterize changes in the coronary arteries. Capillary density index was increased in the MI and OCT+MI groups compared with control. The MI and OCT+MI groups were characterized by irregular vessel arrangements with distorted shape, abrupt changes in vessel direction, as well as abrupt changes in diameter after bifurcations when compared to Sham and OCT. The results indicated that testosterone deficiency attenuates adverse cardiac remodeling after MI. Novel findings in this study were that testosterone deficiency in rats, induced by castration, changes the later remodeling after MI, when compared with non castrated rats. The absence of this androgenous hormone seems to be benefic against pathological hypertrophy. |
format | Online Article Text |
id | pubmed-6428328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64283282019-04-02 Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats Fernandes Corrêa, Rafaela de Araujo Ribeiro Júnior, Rogério Faustino Mendes, Sara Bianca Oliveira dos Santos, Priscila Mendonça da Silva, Miracle Vitória Albino Silva, Daniel Ferron Biral, Igor Peixoto de Batista, Priscila Rossi Vassallo, Dalton Valentim Bittencourt, Athelson Stefanon Stefanon, Ivanita Fernandes, Aurélia Araújo PLoS One Research Article Testosterone is associated with an increased risk of coronary heart disease. This study evaluated cardiac remodeling 60 days after myocardial infarction (MI) in rats with testosterone deficiency. One week after castration, the animals underwent myocardial infarction. Rats were divided into four groups: orchidectomized (OCT); orchidectomized and infarcted (OCT+MI), MI and control (Sham). The myocyte cross-sectional area and the papillary muscle contractility were evaluated 8 weeks after MI. The coronary bed was perfused with Biodur E20 resin to evaluate the neovascularization after MI. Data were expressed as mean ± SEM followed by ANOVA. Castration reduced myocyte hypertrophy when compared to Sham and myocardial infarction alone as well as preserved the contraction force and activation time after myocardial infarction. After beta-adrenergic stimulation, activation and relaxation kinetics were less impaired in the OCT+MI group than in the MI group. Contraction force was preserved in the OCT+MI group after beta-adrenergic stimulation. Multiple scanning electronic microscope images were obtained to characterize changes in the coronary arteries. Capillary density index was increased in the MI and OCT+MI groups compared with control. The MI and OCT+MI groups were characterized by irregular vessel arrangements with distorted shape, abrupt changes in vessel direction, as well as abrupt changes in diameter after bifurcations when compared to Sham and OCT. The results indicated that testosterone deficiency attenuates adverse cardiac remodeling after MI. Novel findings in this study were that testosterone deficiency in rats, induced by castration, changes the later remodeling after MI, when compared with non castrated rats. The absence of this androgenous hormone seems to be benefic against pathological hypertrophy. Public Library of Science 2019-03-21 /pmc/articles/PMC6428328/ /pubmed/30897106 http://dx.doi.org/10.1371/journal.pone.0213351 Text en © 2019 Fernandes Corrêa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fernandes Corrêa, Rafaela de Araujo Ribeiro Júnior, Rogério Faustino Mendes, Sara Bianca Oliveira dos Santos, Priscila Mendonça da Silva, Miracle Vitória Albino Silva, Daniel Ferron Biral, Igor Peixoto de Batista, Priscila Rossi Vassallo, Dalton Valentim Bittencourt, Athelson Stefanon Stefanon, Ivanita Fernandes, Aurélia Araújo Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
title | Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
title_full | Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
title_fullStr | Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
title_full_unstemmed | Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
title_short | Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
title_sort | testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428328/ https://www.ncbi.nlm.nih.gov/pubmed/30897106 http://dx.doi.org/10.1371/journal.pone.0213351 |
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