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A polyvalent coral snake antivenom with broad neutralization capacity

Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are diffi...

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Autores principales: Castillo-Beltrán, María Carlina, Hurtado-Gómez, Juan Pablo, Corredor-Espinel, Vladimir, Ruiz-Gómez, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428337/
https://www.ncbi.nlm.nih.gov/pubmed/30856180
http://dx.doi.org/10.1371/journal.pntd.0007250
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author Castillo-Beltrán, María Carlina
Hurtado-Gómez, Juan Pablo
Corredor-Espinel, Vladimir
Ruiz-Gómez, Francisco Javier
author_facet Castillo-Beltrán, María Carlina
Hurtado-Gómez, Juan Pablo
Corredor-Espinel, Vladimir
Ruiz-Gómez, Francisco Javier
author_sort Castillo-Beltrán, María Carlina
collection PubMed
description Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom.
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spelling pubmed-64283372019-04-01 A polyvalent coral snake antivenom with broad neutralization capacity Castillo-Beltrán, María Carlina Hurtado-Gómez, Juan Pablo Corredor-Espinel, Vladimir Ruiz-Gómez, Francisco Javier PLoS Negl Trop Dis Research Article Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom. Public Library of Science 2019-03-11 /pmc/articles/PMC6428337/ /pubmed/30856180 http://dx.doi.org/10.1371/journal.pntd.0007250 Text en © 2019 Castillo-Beltrán et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Castillo-Beltrán, María Carlina
Hurtado-Gómez, Juan Pablo
Corredor-Espinel, Vladimir
Ruiz-Gómez, Francisco Javier
A polyvalent coral snake antivenom with broad neutralization capacity
title A polyvalent coral snake antivenom with broad neutralization capacity
title_full A polyvalent coral snake antivenom with broad neutralization capacity
title_fullStr A polyvalent coral snake antivenom with broad neutralization capacity
title_full_unstemmed A polyvalent coral snake antivenom with broad neutralization capacity
title_short A polyvalent coral snake antivenom with broad neutralization capacity
title_sort polyvalent coral snake antivenom with broad neutralization capacity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428337/
https://www.ncbi.nlm.nih.gov/pubmed/30856180
http://dx.doi.org/10.1371/journal.pntd.0007250
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