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Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital

BACKGROUND: Antimicrobial stewardship program is a comprehensive, longitudinal program designed to improve and measure the appropriateness of antimicrobial use while increasing patients' safety, decreasing cost of patients' care, and combating emerging antimicrobial resistance. Antimicrobi...

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Autores principales: Jamaati, Hamidreza, Dastan, Farzaneh, Mirshafiei Langari, Zahra, Haghgoo, Roodabeh, Eskandari, Raha, Marjani, Majid, Moniri, Afshin, Hashemian, Seyed Mohammadreza, Farzanegan, Behrooz, Abedini, Atefeh, Tabarsi, Payam, Velayati, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428375/
https://www.ncbi.nlm.nih.gov/pubmed/30915135
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author Jamaati, Hamidreza
Dastan, Farzaneh
Mirshafiei Langari, Zahra
Haghgoo, Roodabeh
Eskandari, Raha
Marjani, Majid
Moniri, Afshin
Hashemian, Seyed Mohammadreza
Farzanegan, Behrooz
Abedini, Atefeh
Tabarsi, Payam
Velayati, Ali Akbar
author_facet Jamaati, Hamidreza
Dastan, Farzaneh
Mirshafiei Langari, Zahra
Haghgoo, Roodabeh
Eskandari, Raha
Marjani, Majid
Moniri, Afshin
Hashemian, Seyed Mohammadreza
Farzanegan, Behrooz
Abedini, Atefeh
Tabarsi, Payam
Velayati, Ali Akbar
author_sort Jamaati, Hamidreza
collection PubMed
description BACKGROUND: Antimicrobial stewardship program is a comprehensive, longitudinal program designed to improve and measure the appropriateness of antimicrobial use while increasing patients' safety, decreasing cost of patients' care, and combating emerging antimicrobial resistance. Antimicrobial resistance, specially emerging multidrug-resistance and extremely drug-resistance gram negative bacteria, is an important concern in the modern world. This is particularly problematic since antimicrobials in production pipelines are not meeting the demand for the emerging resistance micro-organisms; in another word “we are running out of options”. Indiscriminate use of antimicrobial may increase the risk for resistance, and drug toxicity. The aim of this study is to implement an evidence-based antimicrobial stewardship program in a tertiary referral hospital. This study will assure consistency of the stewardship program and measure outcomes to further assess the effectiveness of this program. MATERIALS AND METHODS: After establishment of antimicrobial stewardship committee and endorsement of policies the program will be conducted in all hospital medical wards. In an observational study, all patients receiving antimicrobials included in the program will be closely monitored for primary and secondary outcomes. Hospital's antimicrobial resistance patterns are monitored periodically to assess improvement. The quality indicators will be assessed to ensure proper execution of the program over time. RESULTS: As a study protocol, there are no results available to be reported at this time. CONCLUSION: We are expecting to observe significant reduction in cost of antibiotic use shortly after program execution. By more appropriate utilization of antibiotics patients' safety will be increased. Furthermore, we are expecting to detect improvement in antimicrobial resistance patterns.
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spelling pubmed-64283752019-03-26 Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital Jamaati, Hamidreza Dastan, Farzaneh Mirshafiei Langari, Zahra Haghgoo, Roodabeh Eskandari, Raha Marjani, Majid Moniri, Afshin Hashemian, Seyed Mohammadreza Farzanegan, Behrooz Abedini, Atefeh Tabarsi, Payam Velayati, Ali Akbar Tanaffos Original Article BACKGROUND: Antimicrobial stewardship program is a comprehensive, longitudinal program designed to improve and measure the appropriateness of antimicrobial use while increasing patients' safety, decreasing cost of patients' care, and combating emerging antimicrobial resistance. Antimicrobial resistance, specially emerging multidrug-resistance and extremely drug-resistance gram negative bacteria, is an important concern in the modern world. This is particularly problematic since antimicrobials in production pipelines are not meeting the demand for the emerging resistance micro-organisms; in another word “we are running out of options”. Indiscriminate use of antimicrobial may increase the risk for resistance, and drug toxicity. The aim of this study is to implement an evidence-based antimicrobial stewardship program in a tertiary referral hospital. This study will assure consistency of the stewardship program and measure outcomes to further assess the effectiveness of this program. MATERIALS AND METHODS: After establishment of antimicrobial stewardship committee and endorsement of policies the program will be conducted in all hospital medical wards. In an observational study, all patients receiving antimicrobials included in the program will be closely monitored for primary and secondary outcomes. Hospital's antimicrobial resistance patterns are monitored periodically to assess improvement. The quality indicators will be assessed to ensure proper execution of the program over time. RESULTS: As a study protocol, there are no results available to be reported at this time. CONCLUSION: We are expecting to observe significant reduction in cost of antibiotic use shortly after program execution. By more appropriate utilization of antibiotics patients' safety will be increased. Furthermore, we are expecting to detect improvement in antimicrobial resistance patterns. National Research Institute of Tuberculosis and Lung Disease 2018-03 /pmc/articles/PMC6428375/ /pubmed/30915135 Text en Copyright© 2018 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jamaati, Hamidreza
Dastan, Farzaneh
Mirshafiei Langari, Zahra
Haghgoo, Roodabeh
Eskandari, Raha
Marjani, Majid
Moniri, Afshin
Hashemian, Seyed Mohammadreza
Farzanegan, Behrooz
Abedini, Atefeh
Tabarsi, Payam
Velayati, Ali Akbar
Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital
title Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital
title_full Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital
title_fullStr Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital
title_full_unstemmed Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital
title_short Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital
title_sort study protocol on antimicrobial stewardship in a tertiary respiratory referral hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428375/
https://www.ncbi.nlm.nih.gov/pubmed/30915135
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