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Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient

Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. We present a case of PCP in a 35-year-old male patient with...

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Autores principales: Abolghasemi, Sara, Sharif-Kashani, Babak, Naghashzadeh, Farah, Marjani, Majid, Moniri, Afshin, Doroudinia, Atousa, Tabarsi, Payam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428377/
https://www.ncbi.nlm.nih.gov/pubmed/30915138
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author Abolghasemi, Sara
Sharif-Kashani, Babak
Naghashzadeh, Farah
Marjani, Majid
Moniri, Afshin
Doroudinia, Atousa
Tabarsi, Payam
author_facet Abolghasemi, Sara
Sharif-Kashani, Babak
Naghashzadeh, Farah
Marjani, Majid
Moniri, Afshin
Doroudinia, Atousa
Tabarsi, Payam
author_sort Abolghasemi, Sara
collection PubMed
description Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. We present a case of PCP in a 35-year-old male patient with history of heart transplantation and renal failure who was admitted with a 10-day history of fever, nonproductive cough and elevated level of creatinine with a diagnosis of PCP confirmed by chest radiography and in bronchoalveolar lavage specimens. He was treated with trimethoprim-sulphamethoxazole (SMZ/TMP) and primaquine but treatment was completed with reduced dosage of cotrimoxazole, primaquine and with the addition of caspofungin. This therapy was effective and without any adverse effects in a patient with elevated level of creatinine.
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spelling pubmed-64283772019-03-26 Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient Abolghasemi, Sara Sharif-Kashani, Babak Naghashzadeh, Farah Marjani, Majid Moniri, Afshin Doroudinia, Atousa Tabarsi, Payam Tanaffos Case Report Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. We present a case of PCP in a 35-year-old male patient with history of heart transplantation and renal failure who was admitted with a 10-day history of fever, nonproductive cough and elevated level of creatinine with a diagnosis of PCP confirmed by chest radiography and in bronchoalveolar lavage specimens. He was treated with trimethoprim-sulphamethoxazole (SMZ/TMP) and primaquine but treatment was completed with reduced dosage of cotrimoxazole, primaquine and with the addition of caspofungin. This therapy was effective and without any adverse effects in a patient with elevated level of creatinine. National Research Institute of Tuberculosis and Lung Disease 2018-03 /pmc/articles/PMC6428377/ /pubmed/30915138 Text en Copyright© 2018 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Abolghasemi, Sara
Sharif-Kashani, Babak
Naghashzadeh, Farah
Marjani, Majid
Moniri, Afshin
Doroudinia, Atousa
Tabarsi, Payam
Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
title Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
title_full Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
title_fullStr Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
title_full_unstemmed Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
title_short Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
title_sort caspofungin as salvage therapy for pneumocystis pneumonia in a heart transplant recipient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428377/
https://www.ncbi.nlm.nih.gov/pubmed/30915138
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