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Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient
Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. We present a case of PCP in a 35-year-old male patient with...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Research Institute of Tuberculosis and Lung Disease
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428377/ https://www.ncbi.nlm.nih.gov/pubmed/30915138 |
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author | Abolghasemi, Sara Sharif-Kashani, Babak Naghashzadeh, Farah Marjani, Majid Moniri, Afshin Doroudinia, Atousa Tabarsi, Payam |
author_facet | Abolghasemi, Sara Sharif-Kashani, Babak Naghashzadeh, Farah Marjani, Majid Moniri, Afshin Doroudinia, Atousa Tabarsi, Payam |
author_sort | Abolghasemi, Sara |
collection | PubMed |
description | Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. We present a case of PCP in a 35-year-old male patient with history of heart transplantation and renal failure who was admitted with a 10-day history of fever, nonproductive cough and elevated level of creatinine with a diagnosis of PCP confirmed by chest radiography and in bronchoalveolar lavage specimens. He was treated with trimethoprim-sulphamethoxazole (SMZ/TMP) and primaquine but treatment was completed with reduced dosage of cotrimoxazole, primaquine and with the addition of caspofungin. This therapy was effective and without any adverse effects in a patient with elevated level of creatinine. |
format | Online Article Text |
id | pubmed-6428377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | National Research Institute of Tuberculosis and Lung Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-64283772019-03-26 Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient Abolghasemi, Sara Sharif-Kashani, Babak Naghashzadeh, Farah Marjani, Majid Moniri, Afshin Doroudinia, Atousa Tabarsi, Payam Tanaffos Case Report Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. We present a case of PCP in a 35-year-old male patient with history of heart transplantation and renal failure who was admitted with a 10-day history of fever, nonproductive cough and elevated level of creatinine with a diagnosis of PCP confirmed by chest radiography and in bronchoalveolar lavage specimens. He was treated with trimethoprim-sulphamethoxazole (SMZ/TMP) and primaquine but treatment was completed with reduced dosage of cotrimoxazole, primaquine and with the addition of caspofungin. This therapy was effective and without any adverse effects in a patient with elevated level of creatinine. National Research Institute of Tuberculosis and Lung Disease 2018-03 /pmc/articles/PMC6428377/ /pubmed/30915138 Text en Copyright© 2018 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Abolghasemi, Sara Sharif-Kashani, Babak Naghashzadeh, Farah Marjani, Majid Moniri, Afshin Doroudinia, Atousa Tabarsi, Payam Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient |
title | Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient |
title_full | Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient |
title_fullStr | Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient |
title_full_unstemmed | Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient |
title_short | Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient |
title_sort | caspofungin as salvage therapy for pneumocystis pneumonia in a heart transplant recipient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428377/ https://www.ncbi.nlm.nih.gov/pubmed/30915138 |
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